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Asymmetric Epoxidation Using Iminium Salt Organocatalysts Featuring Dynamically Controlled Atropoisomerism

Published inJournal of organic chemistry, vol. 77, no. 14, p. 6128-6138
Publication date2012
Abstract

Introduction of a pseudoaxial substituent at a stereogenic center adjacent to the nitrogen atom in binaphthyl- and biphenyl-derived azepinium salt organocatalysts affords improved enantioselectivities and yields in the epoxidation of unfunctionalized alkenes. In the biphenyl-derived catalysts, the atropoisomerism at the biphenyl axis is controlled by the interaction of this substituent with the chiral substituent at nitrogen.

Citation (ISO format)
BULMAN PAGE, Philip C. et al. Asymmetric Epoxidation Using Iminium Salt Organocatalysts Featuring Dynamically Controlled Atropoisomerism. In: Journal of organic chemistry, 2012, vol. 77, n° 14, p. 6128–6138. doi: 10.1021/jo300915u
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ISSN of the journal0022-3263
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Creation07/20/2012 9:08:00 AM
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