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Synthesis and characterization of artificial amide-bearing phospholipids

Defense Thèse de doctorat : Univ. Genève, 2012 - Sc. 4420 - 2012/03/21
Abstract Synthesis of artificial phospholipids and investigation of the release behavior patterns is the main and novel point of this dissertation. The concept of the amide-bearing artificial phospholipids is based on the replacement of the natural glycerol backbone found in glycerophosphocholines with new interfaces, such as diaminopropanol. A careful study has revealed that the artificial 1,3-disubstituted amide-bearing phospholipids can bear favorable features that differ drastically from the natural phospholipids in the release behavior of their LUVs. The performed experiments included studies of the spontaneous release of 1,2- and 1,3-disubstituted artificial amide-bearing phospholipids at ambient temperature which describes the intrinsic stability of the sample and the release under increased shearing. The study of the thermodynamic properties, morphology and mechanical properties of phospholipid vesicles was performed. The phase transition behavior of artificial amide-bearing phospholipid bilayers and monolayers and the data obtained from TEM, cryo-TEM, BAM and fluorescent microscopy of GUV were analyzed.
URN: urn:nbn:ch:unige-219316
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FEDOTENKO, Illya. Synthesis and characterization of artificial amide-bearing phospholipids. Université de Genève. Thèse, 2012. https://archive-ouverte.unige.ch/unige:21931

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Deposited on : 2012-07-23

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