The present document will discuss in the first part the etiology, the pathophysiology, the incidence and the natural history of PAD, while in the second part the diagnostic modalities aimed for the detection and the quantification of the PAD will be reviewed. Finally in the third part of the manuscript, the most frequent three clinical scenarios (intermittent claudication, CLI, ALI) will be described, with a special attention to the endovascular approach by treating these pathologies.