Risk of Mental Disorders in Children of Parents with Alcohol or Heroin Dependence: A Controlled High-Risk Study

Vidal, Sonia; Vandeleur, Caroline; Rothen, Stéphane; Gholam-Rezaee, Mehdi; Castelao, Enrique; Halfon, Olivier; Aubry, Jean-Michel; Ferrero, François; Preisig, Martin

doi:10.1159/000337328

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Title		Risk of Mental Disorders in Children of Parents with Alcohol or Heroin Dependence: A Controlled High-Risk Study
Authors		Vidal, Sonia Vandeleur, Caroline Rothen, Stéphane Gholam-Rezaee, Mehdi Castelao, Enrique Halfon, Olivier Aubry, Jean-Michel Ferrero, François Preisig, Martin show all authors [1 - 9]
Published in		European Addiction Research. 2012, vol. 18, no. 5, p. 253-264
Abstract		Aim: To assess the specific effect of alcohol dependence (AD) or heroin dependence (HD) in patients and their spouses on the risk of psychopathology in their 6.0 to 17.9 year-old children (mean 11.3 years). Methods: The sample included 101 offspring of patients with AD, 23 of patients with HD, and 152 of medical controls, as well as their 2 parents. Participants were assessed using semistructured diagnostic interviews and family history reports by psychologists blind to patient diagnoses. Results: Children of HD and AD patients had largely elevated rates of recurrent major depressive disorder. Children of HD patients were also at an increased risk for attention deficit hyperactivity disorder and substance use disorders (SUD). There were interactions between SUD in the 2 parents to increase the risk of SUD in offspring. Conclusions: These results emphasize the need for prompt identification and treatment of these children and highlight the need to pay clinical attention not only to the patient, but also to the co-parent in order to optimize prevention in offspring.
Keywords		Psychopathology — High-risk offspring — Co-parent — Substance use disorders
Identifiers		DOI: 10.1159/000337328
Full text		Article (Accepted version) (170 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté d'économie et de management / Research Center for Statistics
Research group		Thérapeutiques des Troubles de l'Humeur et Anxieux (689)
Citation (ISO format)		VIDAL, Sonia et al. Risk of Mental Disorders in Children of Parents with Alcohol or Heroin Dependence: A Controlled High-Risk Study. In: European Addiction Research, 2012, vol. 18, n° 5, p. 253-264. doi: 10.1159/000337328 https://archive-ouverte.unige.ch/unige:21688