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Doctoral thesis
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English

Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors

Defense date2011-09-06
Abstract

In this thesis work, injectable formulations forming in-situ an implant that entraps superparamagnetic microparticles are developed in view of treating solid tumors by inducing magnetically a local moderate hyperthermia. We first review physical, biological and clinical aspects of induced hyperthermia for cancer treatment, emphasizing electro-magnetic modalities. The in vitro and in vivo investigations of materials and their formulation is then presented. In the next chapter, we characterize the physico-chemical, magnetic and heating properties under an alternating magnetic field (115 kHz, 9 - 12 mT) of silica microparticles embedding superparamagnetic iron oxide nanoparticles (SPIONs) and of selected formulations thereof: an alginate hydrogel and an organogel oof poly(ethylene-co-vinyl alcohol) in dimethysulfoxide). Finally, we demonstrate the therapeutic potential of the superparamagnetic injectable organogel to treat subcutaneous necrotizing solid tumors of human colocarcinoma in a murine model by 20-min magnetic induction of local hyperthemia.

freeng
Keywords
  • Magnetic induced hyperthermia
  • Superparamagnetic nanoparticles (SPIONs)
  • In situ forming implant
  • Physical gels
  • Hydrogels
  • Organogels
  • Silica composite microparticles
  • Subcutaneous xenograft
  • Survival
  • Thermometry
Citation (ISO format)
LE RENARD, Pol-Edern. Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors. 2011. doi: 10.13097/archive-ouverte/unige:21604
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Creation06/07/2012 4:12:00 PM
First validation06/07/2012 4:12:00 PM
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