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Scientific article
Open access
English

Connexin 37 limits thrombus propensity by downregulating platelet reactivity

Published inCirculation, vol. 124, no. 8, p. 930-939
Publication date2011
Abstract

Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to the formation of a stable thrombus are poorly understood. Connexins comprise a family of proteins that form gap junctions enabling intercellular coordination of tissue activity, a process termed gap junctional intercellular communication.

Keywords
  • Adolescent
  • Adult
  • Animals
  • Biotin/analogs & derivatives/pharmacokinetics
  • Bleeding Time
  • Blood Platelets/physiology
  • Connexins/genetics/physiology
  • Down-Regulation/physiology
  • Gap Junctions/physiology
  • Genetic Predisposition to Disease/genetics
  • Humans
  • Male
  • Megakaryocytes/physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Platelet Aggregation/physiology
  • Polymorphism, Genetic/physiology
  • Thrombosis/genetics/physiopathology
  • Young Adult
Citation (ISO format)
ANGELILLO-SCHERRER, Anne et al. Connexin 37 limits thrombus propensity by downregulating platelet reactivity. In: Circulation, 2011, vol. 124, n° 8, p. 930–939. doi: 10.1161/CIRCULATIONAHA.110.015479
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0009-7322
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801downloads

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