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Connexin 37 limits thrombus propensity by downregulating platelet reactivity

Angelillo-Scherrer, Anne
Roth, Isabelle
Sugamele, Rocco
Brisset, Anne
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Published in Circulation. 2011, vol. 124, no. 8, p. 930-9
Abstract Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to the formation of a stable thrombus are poorly understood. Connexins comprise a family of proteins that form gap junctions enabling intercellular coordination of tissue activity, a process termed gap junctional intercellular communication.
Keywords AdolescentAdultAnimalsBiotin/analogs & derivatives/pharmacokineticsBleeding TimeBlood Platelets/physiologyConnexins/genetics/physiologyDown-Regulation/physiologyGap Junctions/physiologyGenetic Predisposition to Disease/geneticsHumansMaleMegakaryocytes/physiologyMiceMice, Inbred C57BLMice, Mutant StrainsPlatelet Aggregation/physiologyPolymorphism, Genetic/physiologyThrombosis/genetics/physiopathologyYoung Adult
PMID: 21810657
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Research groups Geneva Platelet Group (13)
L'athérosclérose (665)
Mucoviscidose et jonctions GAP (229)
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ANGELILLO-SCHERRER, Anne et al. Connexin 37 limits thrombus propensity by downregulating platelet reactivity. In: Circulation, 2011, vol. 124, n° 8, p. 930-9. doi: 10.1161/CIRCULATIONAHA.110.015479 https://archive-ouverte.unige.ch/unige:21574

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Deposited on : 2012-06-13

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