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Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation

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Published in Chimia. 2012, vol. 66, no. 4, p. 241-243
Abstract New sterically hindered chiral N-heterocyclic carbene (NHC) ligands were used in palladium catalysis to bring about a highly enantioselective C(sp3)-H activation on the methylene site of a cycloalkane moiety. The intramolecular coupling reaction of a prochiral N-aryl-N-cycloalkyl methyl carbamate required high temperatures (140-160 °C) and afforded highly enantioenriched trans-2,3-fused indolines.
Keywords Asymmetric CatalysisC-H ActivationChiral NHCIndolinePalladium
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NAKANISHI, Masafumi et al. Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation. In: Chimia, 2012, vol. 66, n° 4, p. 241-243. https://archive-ouverte.unige.ch/unige:21496

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Deposited on : 2012-06-06

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