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Scientific article
English

Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation

Published inChimia, vol. 66, no. 4, p. 241-243
Publication date2012
Abstract

New sterically hindered chiral N-heterocyclic carbene (NHC) ligands were used in palladium catalysis to bring about a highly enantioselective C(sp3)-H activation on the methylene site of a cycloalkane moiety. The intramolecular coupling reaction of a prochiral N-aryl-N-cycloalkyl methyl carbamate required high temperatures (140-160 °C) and afforded highly enantioenriched trans-2,3-fused indolines.

Keywords
  • Asymmetric Catalysis
  • C-H Activation
  • Chiral NHC
  • Indoline
  • Palladium
Citation (ISO format)
NAKANISHI, Masafumi et al. Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines <i>via</i> Inert C(sp<sup>3</sup>)-H Activation. In: Chimia, 2012, vol. 66, n° 4, p. 241–243. doi: 10.2533/chimia.2012.241
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Article (Published version)
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ISSN of the journal0009-4293
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Creation06/05/2012 3:22:00 PM
First validation06/05/2012 3:22:00 PM
Update time03/14/2023 5:37:01 PM
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