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High prevalence of non-B HIV-1 subtypes in seamen and their sexual partners in Croatia

Ramirez-Piedad, Martha Kathleen
Lepej, Snjezana Zidovec
Begovac, Josip
Published in Journal of Medical Virology. 2009, vol. 81, no. 4, p. 573-7
Abstract Travel influences the spread of non-B subtypes of HIV in Europe. The aim of this study was to assess whether the spread of non-B subtypes occurred in Croatia, a country with a low level HIV infection. Phylogenetic analysis of the reverse transcriptase and protease genes was undertaken in 145 Croatian patients with the following risks for HIV-infection: men who have sex with men (n = 64), heterosexual contact (n = 54), intravenous drug use (n = 21), bisexual contact (n = 4) and intravenous drug use plus heterosexual exposure (n = 2). The sample included 25 seamen and 13 steady female sexual partners of seamen. Overall, 38 (26%) of HIV-patients were infected with non-B subtypes. Non-B subtype infections were found only in patients with a possible heterosexual exposure. Non-B infections were most frequent in seamen and their regular female partners (in 27 of 38 seamen and their partners, 71%). The relative distribution of non-B subtypes was as follows: A, 8%; C, 26%; F, 3%; CRF01_AE, 8%; CRF02_AG, 34%; CRF05_DF, 5%; CRF06_cpx, 3%; CRF10_CD 8%; and subtype U, 5%. There were altogether 19 heterosexual couples, phylogenetic analysis confirmed that the paired samples were related in all cases. Non-B subtypes were found only in individuals with a heterosexual risk, mainly in seamen and their partners.
Keywords AdultCroatia/epidemiologyFemaleHIV Infections/epidemiology/transmission/virologyHIV Protease/geneticsHIV Reverse Transcriptase/geneticsHIV-1/classification/enzymology/genetics/isolation & purificationHeterosexualityHumansMalePhylogenyPrevalenceRisk-TakingSequence Analysis, DNASexual BehaviorSexual PartnersTransients and MigrantsTravel
PMID: 19235840
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RAMIREZ-PIEDAD, Martha Kathleen et al. High prevalence of non-B HIV-1 subtypes in seamen and their sexual partners in Croatia. In: Journal of Medical Virology, 2009, vol. 81, n° 4, p. 573-7. https://archive-ouverte.unige.ch/unige:21416

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Deposited on : 2012-05-24

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