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Title

Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT

Authors
Valenta, Ines
Vincenti, Gabriella
Dewarrat, Stephan
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Published in Journal of Nuclear Cardiology. 2010, vol. 17, no. 6, p. 1023-1033
Abstract BACKGROUND: The aim of this study was to determine whether epicardial structural disease may affect the manifestation of a longitudinal decrease in myocardial blood flow (MBF) or MBF difference during hyperemia in cardiovascular risk individuals, and its dependency on the flow increase. METHODS AND RESULTS: In 54 cardiovascular risk individuals (at risk) and in 26 healthy controls, MBF was measured with (13)N-ammonia and PET/CT in mL/g/min at rest and during dipyridamole stimulation. Computed tomography coronary angiography (CTA) was performed using a 64-slice CT of a PET/CT system. Absolute MBFs during dipyridamole stimulation were mildly lower in the mid-distal than in the mid-LV myocardium in controls (2.20 +/- .51 vs 2.29 +/- .51, P < .0001), while it was more pronounced in at risk with normal and abnormal CTA (1.56 +/- .42 vs 1.91 +/- .46 and 1.18 +/- .34 vs 1.51 +/- .40 mL/g/min, respectively, P < .0001), resulting in a longitudinal MBF difference that was highest in at risk with normal CTA, intermediate in at risk abnormal CTA, and lowest in controls (.35 +/- .16 and .22 +/- .09 vs .09 +/- .04 mL/g/min, respectively, P < .0001). On multivariate analysis, log-CCS and mid-LV hyperemic MBF increase, indicative of microvascular function, were independent predictors of the observed longitudinal MBF difference (P </= .004 by ANOVA). CONCLUSIONS: Epicardial structural disease and microvascular function are important determinants of an abnormal longitudinal MBF difference as determined with PET/CT.
Keywords AdultAgedCardiovascular Diseases/*diagnosis/*pathology/radiographyCase-Control StudiesCoronary CirculationFemaleHumansMaleMicrocirculationMiddle AgedMyocardium/*pathologyPericardium/*pathologyPositron-Emission Tomography/*methodsRiskTomography, X-Ray Computed/*methods
Identifiers
PMID: 20658271
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Structures
Research groups Biologie du myocarde (22)
Imagerie Médicale (TEP et TEMP) (542)
L'athérosclérose et ses complications cliniques (591)
Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
Groupe Schindler Thomas (cardiologie) (890)
Cyclotron (897)
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(ISO format)
VALENTA, Ines et al. Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT. In: Journal of Nuclear Cardiology, 2010, vol. 17, n° 6, p. 1023-1033. https://archive-ouverte.unige.ch/unige:21359

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Deposited on : 2012-05-23

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