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Title

Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery

Authors
Tejpar, Sabine
Bertagnolli, Monica
Bosman, Fred
Lenz, Heinz-Joseph
Garraway, Levi
Waldman, Frederic
Warren, Robert
Bild, Andrea
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Published in The Oncologist. 2010, vol. 15, no. 4, p. 390-404
Abstract The number of agents that are potentially effective in the adjuvant treatment of locally advanced resectable colon cancer is increasing. Consequently, it is important to ascertain which subgroups of patients will benefit from a specific treatment. Despite more than two decades of research into the molecular genetics of colon cancer, there is a lack of prognostic and predictive molecular biomarkers with proven utility in this setting. A secondary objective of the Pan European Trials in Adjuvant Colon Cancer-3 trial, which compared irinotecan in combination with 5-fluorouracil and leucovorin in the postoperative treatment of stage III and stage II colon cancer patients, was to undertake a translational research study to assess a panel of putative prognostic and predictive markers in a large colon cancer patient cohort. The Cancer and Leukemia Group B 89803 trial, in a similar design, also investigated the use of prognostic and predictive biomarkers in this setting. In this article, the authors, who are coinvestigators from these trials and performed similar investigations of biomarker discovery in the adjuvant treatment of colon cancer, review the current status of biomarker research in this field, drawing on their experiences and considering future strategies for biomarker discovery in the postgenomic era.
Keywords Chemotherapy, AdjuvantColorectal Neoplasms/ genetics/pathology/therapyDisease ProgressionGenes, p53/geneticsGenomic InstabilityGenomicsHumansMicrosatellite InstabilityPhenotypePredictive Value of TestsPrognosisProto-Oncogene Proteins/geneticsProto-Oncogene Proteins B-raf/geneticsTumor Markers, BiologicalRas Proteins/genetics
Identifiers
PMID: 20350999
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Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://theoncologist.alphamedpress.org/
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Research group Groupe Roth Arnaud (oncologie) (285)
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TEJPAR, Sabine et al. Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. In: The Oncologist, 2010, vol. 15, n° 4, p. 390-404. https://archive-ouverte.unige.ch/unige:21333

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Deposited on : 2012-05-23

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