UNIGE document Scientific Article
previous document  unige:21320  next document
add to browser collection
Title

Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients

Authors
Aubert, J-D
Rochat, T. S.
Meylan, P.
show hidden authors show all authors [1 - 10]
Published in Clinical Infectious Diseases. 2010, vol. 51, no. 2, p. 163-170
Abstract BACKGROUND: Lung transplant recipients are frequently exposed to respiratory viruses and are particularly at risk for severe complications. The aim of this study was to assess the association among the presence of a respiratory virus detected by molecular assays in bronchoalveolar lavage (BAL) fluid, respiratory symptoms, and acute rejection in adult lung transplant recipients. METHODS: Upper (nasopharyngeal swab) and lower (BAL) respiratory tract specimens from 77 lung transplant recipients enrolled in a cohort study and undergoing bronchoscopy with BAL and transbronchial biopsies were screened using 17 different polymerase chain reaction-based assays. RESULTS: BAL fluid and biopsy specimens from 343 bronchoscopic procedures performed in 77 patients were analyzed. We also compared paired nasopharyngeal and BAL fluid specimens collected in a subgroup of 283 cases. The overall viral positivity rate was 29.3% in the upper respiratory tract specimens and 17.2% in the BAL samples (P < .001). We observed a significant association between the presence of respiratory symptoms and positive viral detection in the lower respiratory tract (P = .012). Conversely, acute rejection was not associated with the presence of viral infection (odds ratio, 0.41; 95% confidence interval, 0.20-0.88). The recovery of lung function was significantly slower when acute rejection and viral infection were both present. CONCLUSIONS: A temporal relationship exists between acute respiratory symptoms and positive viral nucleic acid detection in BAL fluid from lung transplant recipients. We provide evidence suggesting that respiratory viruses are not associated with acute graft rejection during the acute phase of infection.
Keywords AdolescentAdultAgedBronchoalveolar Lavage Fluid/virologyChildCohort StudiesFemaleGraft Rejection/*complicationsHumans*Lung TransplantationMaleMiddle AgedNasopharynx/virologyRespiratory Tract Infections/*complications/virology*TransplantationVirus Diseases/*complicationsViruses/isolation & purificationYoung Adult
Identifiers
PMID: 20524853
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://cid.oxfordjournals.org/content/51/2/163.full.pdf
Structures
Research groups Pneumologie Clinique (576)
Groupe Laurent Kaiser (virologie clinique) (668)
L'épithélium respiratoire (852)
Citation
(ISO format)
GASCHE-SOCCAL, Paola Marina Alessandra et al. Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients. In: Clinical Infectious Diseases, 2010, vol. 51, n° 2, p. 163-170. https://archive-ouverte.unige.ch/unige:21320

191 hits

1 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :