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Title

Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling

Authors
Bertolotto, Maria
Ottonello, Luciano
Pende, Aldo
Dallegri, Franco
Published in European Journal of Clinical Investigation. 2010, vol. 40, no. 7, p. 645-654
Abstract BACKGROUND: Coronary artery disease (CAD) represents the most relevant cause of death and morbidity in the adult population of developed and developing countries. During the last decades, a strong research effort has been performed to identify more selective markers and better assess the cardiovascular risk in both primary and secondary prevention. MATERIALS AND METHODS: This review updates current knowledge regarding the pathophysiological relevance as possible markers of coronary calcification of the receptor activator of nuclear factor-kappa ligand (RANKL)/osteoprotegerin (OPG) system. Furthermore, the potential clinical use of both RANKL/OPG and coronary calcium score (CAC) to assess cardiovascular vulnerability has been discussed. RESULTS: Emerging evidence indicates that atherosclerotic plaque calcification is positively correlated with vulnerability. Several inflammatory mediators have been shown to modulate arterial calcification, thus increasing the risk of plaque rupture. Among these factors, RANKL/OPG axis might be of particular interest as a promising biomarker of plaque vulnerability in subjects with diffuse coronary calcification. CONCLUSION: Together with clinical parameters of coronary calcification (such as CAC), circulating RANKL/OPG levels could contribute to better assess and predict cardiac events.
Keywords Biological Markers/blood/*metabolismCalcinosis/*blood/metabolismCardiovascular Diseases/*etiologyCoronary Artery Disease/blood/*complicationsHumansOsteoprotegerin/*blood/metabolismRANK Ligand/*bloodReceptor Activator of Nuclear Factor-kappa B/*bloodRisk Factors
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PMID: 20497460
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
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QUERCIOLI, Alessandra et al. Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling. In: European Journal of Clinical Investigation, 2010, vol. 40, n° 7, p. 645-654. https://archive-ouverte.unige.ch/unige:21240

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Deposited on : 2012-05-23

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