Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?

Posfay Barbe, Klara; Kobela, Marie; Sottas, Cédric Ernest; Grillet, Stéphane; Taguebue, Jean; Ekoe, Tetanye; Lambert, Paul Henri; Lecoultre, Claude; Siegrist, Claire-Anne

doi:10.1016/j.vaccine.2010.04.060

Scientific article

English

Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?

ContributorsPosfay Barbe, Klara; Kobela, Marie; Sottas, Cédric Ernest; Grillet, Stéphane; Taguebue, Jean; Ekoe, Tetanye; Lambert, Paul Henri; Lecoultre, Claude; Siegrist, Claire-Anne

Published inVaccine, vol. 28, no. 27, p. 4356-4361

Publication date2010

Abstract

To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥ 4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10UI/ml threshold. Response rates were slightly higher (62%) in children aged 10-11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.

Keywords

Adolescent
Antibodies, Bacterial/immunology
Child
Female
Humans
*Immunization
*Immunization, Secondary
Infant
Male
Tetanus Toxoid/*administration & dosage/*immunology

Affiliation

Research group

Citation (ISO format)

POSFAY BARBE, Klara et al. Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory? In: Vaccine, 2010, vol. 28, n° 27, p. 4356–4361. doi: 10.1016/j.vaccine.2010.04.060

Article

Identifiers

PID : unige:21227
DOI : 10.1016/j.vaccine.2010.04.060
PMID : 20447475

Commercial URLhttp://ac.els-cdn.com/S0264410X10005840/1-s2.0-S0264410X10005840-main.pdf?_tid=f62dd6956d043c10bfe7eeaa983ebf57&acdnat=1335969598_52c9f9cb8fadfc5ee1a7a358c2660c67

ISSN of the journal0264-410X

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Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?

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