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Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?
|Published in||Vaccine. 2010, vol. 28, no. 27, p. 4356-4361|
|Abstract||To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥ 4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10UI/ml threshold. Response rates were slightly higher (62%) in children aged 10-11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.|
|Keywords||Adolescent — Antibodies, Bacterial/immunology — Child — Female — Humans — *Immunization — *Immunization, Secondary — Infant — Male — Tetanus Toxoid/*administration & dosage/*immunology|
|Research groups||Centre de Vaccinologie et d'Immunologie néonatale (177)|
Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
Recherche clinique en chirurgie pédiatrique (886)
|POSFAY BARBE, Clara et al. Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?. In: Vaccine, 2010, vol. 28, n° 27, p. 4356-4361. https://archive-ouverte.unige.ch/unige:21227|