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Title

Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?
Authors
Posfay Barbe, Klara
Kobela, Marie
Sottas, Cédric Ernest
Grillet, Stéphane
Taguebue, Jean
Ekoe, Tetanye
Lambert, Paul Henri
Lecoultre, Claude
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Published in Vaccine. 2010, vol. 28, no. 27, p. 4356-4361
Abstract To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥ 4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10UI/ml threshold. Response rates were slightly higher (62%) in children aged 10-11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.
Keywords Adolescent — Antibodies, Bacterial/immunology — Child — Female — Humans — *Immunization — *Immunization, Secondary — Infant — Male — Tetanus Toxoid/*administration & dosage/*immunology
Identifiers
PMID: 20447475
Full text
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Recherche clinique en chirurgie pédiatrique (886)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Citation
(ISO format) 		POSFAY BARBE, Klara et al. Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?. In: Vaccine, 2010, vol. 28, n° 27, p. 4356-4361. doi: 10.1016/j.vaccine.2010.04.060 https://archive-ouverte.unige.ch/unige:21227

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Deposited on : 2012-05-23

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