UNIGE document Scientific Article
previous document  unige:21220  next document
add to browser collection
Title

Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study

Authors
Plessier, Aurelie
Darwish-Murad, Sarwa
Hernandez-Guerra, Manuel
Consigny, Yann
Fabris, Federica
Trebicka, Jonel
Heller, Jorg
show hidden authors show all authors [1 - 18]
Published in Hepatology. 2010, vol. 51, no. 1, p. 210-218
Abstract Current recommendations for early anticoagulation in acute portal vein thrombosis unrelated to cirrhosis or malignancy are based on limited evidence. The aim of this study was to prospectively assess the risk factors, outcome, and prognosis in patients managed according to these recommendations. We enrolled 102 patients with acute thrombosis of the portal vein, or its left or right branch. Laboratory investigations for prothrombotic factors were centralized. Thrombus extension and recanalization were assessed by expert radiologists. A local risk factor was identified in 21% of patients, and one or several general prothrombotic conditions in 52%. Anticoagulation was given to 95 patients. After a median of 234 days, the portal vein and its left or right branch were patent in 39% of anticoagulated patients (versus 13% initially), the splenic vein in 80% (versus 57% initially), and the superior mesenteric vein in 73% (versus 42% initially). Failure to recanalize the portal vein was independently related to the presence of ascites (hazard ratio 3.8, 95% confidence interval 1.3-11.1) and an occluded splenic vein (hazard ratio 3.5, 95% confidence interval 1.4-8.9). Gastrointestinal bleeding and intestinal infarction occurred in nine and two patients, respectively. Two patients died from causes unrelated to thrombosis or anticoagulation therapy. CONCLUSION: Recanalization occurs in one-third of patients receiving early anticoagulation for acute portal vein thrombosis, whereas thrombus extension, intestinal infarction, severe bleeding, and death are rare. Alternative therapy should be considered when ascites and splenic vein obstruction are present.
Keywords Acute DiseaseAdolescentAdultAgedAged, 80 and overAnticoagulants/ therapeutic useAscites/complicationsFemaleFollow-Up StudiesHumansLiver Cirrhosis/ complicationsMaleMesenteric Veins/radiographyMiddle AgedPortal Vein/ radiographyProspective StudiesRisk FactorsSplenic Vein/radiographyTreatment OutcomeVenous Thrombosis/drug therapy/ etiology/radiography
Identifiers
PMID: 19821530
Full text
Structures
Citation
(ISO format)
PLESSIER, Aurelie et al. Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. In: Hepatology, 2010, vol. 51, n° 1, p. 210-218. https://archive-ouverte.unige.ch/unige:21220

243 hits

0 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :