Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
Contributeurs/tricesPierroz, Dominique D.; Bonnet, Nicolas; Baldock, Paul A.; Ominsky, Michael S.; Stolina, Marina; Kostenuik, Paul J.; Ferrari, Serge Livio
Publié dansThe Journal of biological chemistry, vol. 285, no. 36, p. 28164-28173
Date de publication2010
Résumé
Mots-clés
- Alendronate/administration & dosage/*pharmacology
- Animals
- Antibodies, Monoclonal/administration & dosage/*pharmacology
- Biological Markers/metabolism
- Bone Density/drug effects
- Bone Resorption/drug therapy
- Bone and Bones/cytology/drug effects/*metabolism/physiology
- Dose-Response Relationship, Drug
- Female
- Gene Expression
- *Gene Knock-In Techniques
- Humans
- Male
- Mice
- Osteoclasts/*drug effects/metabolism
- Osteogenesis/drug effects
- Ovariectomy
- Parathyroid Hormone/administration & dosage/*pharmacology
- RANK Ligand/administration & dosage/*pharmacology
- Receptor Activator of Nuclear Factor-kappa B/antagonists & inhibitors/deficiency/*genetics/metabolism
Groupe de recherche
Citation (format ISO)
PIERROZ, Dominique D. et al. Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. In: The Journal of biological chemistry, 2010, vol. 285, n° 36, p. 28164–28173. doi: 10.1074/jbc.M110.101964
Correctifs (1)
Article

Identifiants
- PID : unige:21214
- DOI : 10.1074/jbc.M110.101964
- PMID : 20558734
URL commercialhttp://www.jbc.org/content/285/36/28164.full.pdf
ISSN du journal0021-9258