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Scientific Article
unige:21200 
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Delayed production of IL-18 in lungs and pancreas of rats with acute pancreatitis |
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| Authors | ||
| Published in | Pancreatology. 2010, vol. 10, no. 6, p. 752-757 | |
| Abstract | BACKGROUND/AIMS: During acute pancreatitis, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 and IL-6 play a pivotal role in promoting injury in the pancreas and remote organs. IL- 18 is a more recently discovered proinflammatory cytokine whose expression is also increased in serum. However, the profile of IL-18 expression in the pancreas and lung is unknown, and the aim of our study was to investigate such expression in rats with pancreatitis. METHODS: Acute pancreatitis was induced by taurocholic acid and endotoxin. Pulmonary and pancreatic injury was measured by biological and histological parameters. Lung injury was also evaluated in ex vivo lung preparations. RESULTS: Pancreatic and pulmonary injury appeared within 2 h after pancreatitis induction and persisted until the end of the protocol (18 h). TNF-alpha, IL-1 and IL-6 expression increased early in the lungs and pancreas, with a partial recovery by the end of the study. In contrast, IL-18 increased mostly by the end of the protocol (18 h after pancreatitis induction). CONCLUSION: IL-18 may serve as an additional marker to monitor the severity of inflammation during pancreatitis since its tissue production is delayed and appears after that of more commonly investigated cytokines. and IAP. | |
| Keywords | Acute Disease — Acute Lung Injury/chemically induced/*metabolism/pathology — Animals — Disease Models, Animal — Drug Therapy, Combination — Endotoxins/toxicity — Interleukin-1/metabolism — Interleukin-18/*metabolism — Interleukin-6/metabolism — Lung/drug effects/*metabolism/pathology — Pancreas/drug effects/metabolism/pathology — Pancreatitis/chemically induced/*metabolism/pathology — Rats — Rats, Sprague-Dawley — Taurocholic Acid/toxicity — Tumor Necrosis Factor-alpha/metabolism | |
| Identifiers | DOI: 10.1159/000317283 PMID: 21273803 | |
| Full text |
Article - Limited access to UNIGE Other version: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000317283&Ausgabe=254741&ProduktNr=224334&... |
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| Structures |
Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences |
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| Research groups | Physiopathologie de la pancréatite aiguë (601) Pharmacologie et imagerie du foie (664) Chimie et protéomique clinique (270) | |
| Citation (ISO format) | PASTOR, Catherine et al. Delayed production of IL-18 in lungs and pancreas of rats with acute pancreatitis. In: Pancreatology, 2010, vol. 10, n° 6, p. 752-757. doi: 10.1159/000317283 https://archive-ouverte.unige.ch/unige:21200 |
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