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Outcomes of patients on dual-boosted PI regimens: experience of the Swiss HIV cohort study

Authors
Osih, Regina B.
Rickenbach, Martin
Elzi, Luigia
Fux, Christoph
Opravil, Milos
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Published in AIDS Research and Human Retroviruses. 2010, vol. 26, no. 11, p. 1239-1246
Abstract Dual-boosted protease inhibitors (DBPI) are an option for salvage therapy for HIV-1 resistant patients. Patients receiving a DBPI in the Swiss HIV Cohort Study between January1996 and March 2007 were studied. Outcomes of interest were viral suppression at 24 weeks. 295 patients (72.5%) were on DBPI for over 6 months. The median duration was 2.2 years. Of 287 patients who had HIV-RNA >400 copies/ml at the start of the regimen, 184 (64.1%) were ever suppressed while on DBPI and 156 (54.4%) were suppressed within 24 weeks. The median time to suppression was 101 days (95% confidence interval 90-125 days). The median number of past regimens was 6 (IQR, 3-8). The main reasons for discontinuing the regimen were patient's wish (48.3%), treatment failure (22.5%), and toxicity (15.8%). Acquisition of HIV through intravenous drug use and the use of lopinavir in combination with saquinavir or atazanavir were associated with an increased likelihood of suppression within 6 months. Patients on DBPI are heavily treatment experienced. Viral suppression within 6 months was achieved in more than half of the patients. There may be a place for DBPI regimens in settings where more expensive alternates are not available.
Keywords AdultAnti-HIV Agents/*administration & dosage/adverse effectsAntiretroviral Therapy, Highly Active/adverse effects/*methodsCohort StudiesFemaleHIV Infections/*drug therapyHIV Protease Inhibitors/*administration & dosage/adverse effectsHIV-1/isolation & purificationHumansMaleMiddle AgedRNA, Viral/bloodSalvage Therapy/adverse effects/*methodsSwitzerlandTime FactorsTreatment FailureTreatment OutcomeViral Load
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PMID: 20929393
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OSIH, Regina B. et al. Outcomes of patients on dual-boosted PI regimens: experience of the Swiss HIV cohort study. In: AIDS Research and Human Retroviruses, 2010, vol. 26, n° 11, p. 1239-1246. https://archive-ouverte.unige.ch/unige:21197

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Deposited on : 2012-05-23

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