en
Scientific article
English

Outcomes of patients on dual-boosted PI regimens: experience of the Swiss HIV cohort study

Published inAIDS research and human retroviruses, vol. 26, no. 11, p. 1239-1246
Publication date2010
Abstract

Dual-boosted protease inhibitors (DBPI) are an option for salvage therapy for HIV-1 resistant patients. Patients receiving a DBPI in the Swiss HIV Cohort Study between January1996 and March 2007 were studied. Outcomes of interest were viral suppression at 24 weeks. 295 patients (72.5%) were on DBPI for over 6 months. The median duration was 2.2 years. Of 287 patients who had HIV-RNA >400 copies/ml at the start of the regimen, 184 (64.1%) were ever suppressed while on DBPI and 156 (54.4%) were suppressed within 24 weeks. The median time to suppression was 101 days (95% confidence interval 90-125 days). The median number of past regimens was 6 (IQR, 3-8). The main reasons for discontinuing the regimen were patient's wish (48.3%), treatment failure (22.5%), and toxicity (15.8%). Acquisition of HIV through intravenous drug use and the use of lopinavir in combination with saquinavir or atazanavir were associated with an increased likelihood of suppression within 6 months. Patients on DBPI are heavily treatment experienced. Viral suppression within 6 months was achieved in more than half of the patients. There may be a place for DBPI regimens in settings where more expensive alternates are not available.

Keywords
  • Adult
  • Anti-HIV Agents/*administration & dosage/adverse effects
  • Antiretroviral Therapy, Highly Active/adverse effects/*methods
  • Cohort Studies
  • Female
  • HIV Infections/*drug therapy
  • HIV Protease Inhibitors/*administration & dosage/adverse effects
  • HIV-1/isolation & purification
  • Humans
  • Male
  • Middle Aged
  • RNA, Viral/blood
  • Salvage Therapy/adverse effects/*methods
  • Switzerland
  • Time Factors
  • Treatment Failure
  • Treatment Outcome
  • Viral Load
Citation (ISO format)
OSIH, Regina B. et al. Outcomes of patients on dual-boosted PI regimens: experience of the Swiss HIV cohort study. In: AIDS research and human retroviruses, 2010, vol. 26, n° 11, p. 1239–1246. doi: 10.1089/aid.2010.0070
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ISSN of the journal0889-2229
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