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Molecular biology of breast cancer stem cells: potential clinical applications

Almeida, Fabio S.
Chi, Alex
Nguyen, Ly M.
Cohen, Deirdre
Karlsson, Ulf
Published in Cancer Treatment Reviews. 2010, vol. 36, no. 6, p. 485-491
Abstract Breast cancer stem cells (CSC) have been postulated recently as responsible for failure of breast cancer treatment. The purpose of this study is to review breast CSCs molecular biology with respect to their mechanism of resistance to conventional therapy, and to develop treatment strategies that may improve survival of breast cancer patients. A literature search has identified in vitro and in vivo studies of breast CSCs. Breast CSCs overexpress breast cancer resistance protein (BCRP) which allows cancer cells to transport actively chemotherapy agents out of the cells. Radioresistance is modulated through activation of Wnt signaling pathway and overexpression of genes coding for glutathione. Lapatinib can selectively target HER-2 positive breast CSCs and improves disease-free survival in these patients. Metformin may target basal type breast CSCs. Parthenolide and oncolytic viruses are promising targeting agents for breast CSCs. Future clinical trials for breast cancer should include anti-cancer stem cells targeting agents in addition to conventional chemotherapy. Hypofractionation radiotherapy may be indicated for residual disease post chemotherapy.
Keywords Antineoplastic Agents/metabolism/therapeutic useBreast Neoplasms/metabolism/*pathology/therapyDrug Delivery Systems/methods/trendsDrug Resistance, Neoplasm/*physiologyFemaleHumansMolecular Biology/methods/trendsNeoplastic Stem Cells/drug effects/*pathology/radiation effectsOncolytic Viruses/metabolismRadiation Tolerance/*physiologySignal Transduction/drug effects/*physiology/radiation effects
PMID: 20231058
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NGUYEN, Nam et al. Molecular biology of breast cancer stem cells: potential clinical applications. In: Cancer Treatment Reviews, 2010, vol. 36, n° 6, p. 485-491. doi: 10.1016/j.ctrv.2010.02.016 https://archive-ouverte.unige.ch/unige:21184

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Deposited on : 2012-05-23

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