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IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma

Rai, Har
Tchabo, Nana
Lele, Shashikant
Izevbaye, Iyare
Odunsi, Kunle
Cheney, Richard T.
Published in American Journal of Clinical Pathology. 2010, vol. 133, no. 6, p. 899-908
Abstract Differentiating uterine serous carcinoma (USC) from endometrioid adenocarcinoma (EAC) could be problematic, especially in high-grade EACs and tumors exhibiting architectural variations. To address this issue, we evaluated 103 endometrial carcinoma cases using 4 immunomarkers, beta-catenin, IMP3, PTEN, and p53. Cases included 31 USCs, 57 EACs, and 15 mixed EAC-USCs. Of 31 USCs and 57 EACs, 8 and 9, respectively, were considered diagnostically difficult and challenging. beta-catenin was more frequently expressed in EAC (P = .001); p53, PTEN, and IMP3 were more frequently found in USC (P < .001 for each). IMP3 was the best independent predictive marker for USCs. The best marker combination for predicting USCs was PTEN+/IMP3+ (exact odds ratio, 163.87; 95% confidence interval, 19.62 to infinity; P < .001). IMP3 was consistently negative in all 9 challenging EAC cases and consistently positive in all 8 challenging USC cases. None of the markers or their combinations demonstrated any value in making the diagnosis of serous component in mixed EAC-USC tumors. IMP3 immunoexpression and the IMP3+/PTEN+ pattern are the best independent and combination markers, respectively, to predict USCs. We strongly recommend using them in difficult and challenging cases.
Keywords AdultAgedAged, 80 and overCarcinoma, Endometrioid/diagnosis/*pathologyCystadenocarcinoma, Serous/diagnosis/*pathologyDiagnosis, DifferentialFemaleHumansMiddle AgedPTEN Phosphohydrolase/*analysisRNA-Binding Proteins/*analysisRetrospective StudiesTumor Markers, Biological/*analysisTumor Suppressor Protein p53/analysisUterine Neoplasms/diagnosis/*pathologyBeta Catenin/analysis
PMID: 20472848
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Other version: http://ajcp.ascpjournals.org/content/133/6/899.full.pdf
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MHAWECH-FAUCEGLIA, Paulette et al. IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma. In: American Journal of Clinical Pathology, 2010, vol. 133, n° 6, p. 899-908. https://archive-ouverte.unige.ch/unige:21141

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Deposited on : 2012-05-23

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