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Title

Adverse prognostic significance of CD20 expression in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia

Authors
Maury, Sébastien
Huguet, Francoise
Leguay, Thibaut
Lacombe, Francis
Maynadie, Marc
Girard, Sandrine
de Labarthe, A.
Kuhlein, E.
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Published in Haematologica. 2010, vol. 95, no. 2, p. 324-328
Abstract The prognostic significance of CD20 expression in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has been mostly studied in children and yielded conflicting results. In 143 adults with Philadelphia chromosome-negative BCP-ALL treated in the multicentric GRAALL 2003 trial, CD20 positivity over 20% was observed in 32% of patients. While not influencing complete remission achievement, CD20 expression was associated with a higher cumulative incidence of relapse (CIR) at 42 months (P=0.04), independently of the ALL high-risk subset (P=0.025). Notably, the negative impact of CD20 expression on CIR was only observed in patients with a white blood cell count (WBC) over 30x10(9)/L (P=0.006), while not in those with a lower WBC. In the former subgroup, this impact translated into lower event-free survival (15% vs. 59% at 42 months, P=0.003). CD20 expression thus appears to be associated with a worse outcome, which reinforces the interest of evaluating rituximab combined to chemotherapy in CD20-positive adult BCP-ALL. ClinicalTrials.gov ID, NCT00222027.
Keywords Acute DiseaseAdolescentAdultAntigens, CD20/*diagnostic use/*geneticsClinical Trials as Topic*Gene ExpressionHumansLeukocyte CountMiddle AgedPhiladelphia ChromosomePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/*genetics/therapyPrognosisRecurrenceYoung Adult
Identifiers
PMID: 19773266
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MAURY, Sébastien et al. Adverse prognostic significance of CD20 expression in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia. In: Haematologica, 2010, vol. 95, n° 2, p. 324-328. https://archive-ouverte.unige.ch/unige:21126

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Deposited on : 2012-05-23

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