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Mode of action of adjuvants: implications for vaccine safety and design

Ahmed, Sohail
Egan, William M.
Golding, Hana
Gust, Ian
Neels, Pieter
Reed, Steven G.
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Published in Biologicals. 2010, vol. 38, no. 5, p. 594-601
Abstract For decades, the search for new vaccine adjuvants has been largely empirical. A series of new adjuvants and related formulations are now emerging that are acting through identified immunological mechanisms. Understanding adjuvant mechanism of action is crucial for vaccine design, since this allows for directing immune responses towards efficacious disease-specific effector mechanisms and appropriate memory. It is also of great importance to build new paradigms for assessing adjuvant safety at development stages and at regulatory level. This report reflects the conclusions of a group of scientists from academia, regulatory agencies and industry who attended a conference, organized by the International Association for Biologicals (IABS), on the mode of action of adjuvants on 29-30 April 2010 in Bethesda, Maryland, USA, particularly focusing on how understanding adjuvants mode of action can impact on the assessment of vaccine safety and help to develop target-specific vaccines. More information on the conference output can be found on the IABS website, http://www.iabs.org/.
Keywords Adjuvants, Immunologic/*adverse effects/*pharmacologyAnimalsChemistry, Pharmaceutical/methods/trendsCommunicable Diseases/therapyDrug Compounding/methodsDrug DesignHumansInfluenza A Virus, H1N1 Subtype/immunologyInfluenza, Human/epidemiology/prevention & control/therapyMarylandMass Vaccination/adverse effectsPandemicsPublic Health/methods/trendsSafetyUnited StatesVaccines/*adverse effects
PMID: 20659806
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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MASTELIC-GAVILLET, Beatris et al. Mode of action of adjuvants: implications for vaccine safety and design. In: Biologicals, 2010, vol. 38, n° 5, p. 594-601. doi: 10.1016/j.biologicals.2010.06.002 https://archive-ouverte.unige.ch/unige:21121

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Deposited on : 2012-05-23

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