UNIGE document Scientific Article
previous document  unige:21109  next document
add to browser collection
Title

Impact of procalcitonin on the management of children aged 1 to 36 months presenting with fever without source: a randomized controlled trial

Authors
Bailey, Benoit
Girodias, Jean-Bernard
Cousineau, Jocelyne
Delvin, Edgard
Published in The American Journal of Emergency Medicine. 2010, vol. 28, no. 6, p. 647-653
Abstract OBJECTIVE: The aim of the study was to evaluate the impact of procalcitonin (PCT) measurement on antibiotic use in children with fever without source. METHOD: Children aged 1 to 36 months presenting to a pediatric emergency department (ED) with fever and no identified source of infection were eligible to be included in a randomized controlled trial. Patients were randomly assigned to 1 of 2 groups as follows: PCT+ (result revealed to the attending physician) and PCT- (result not revealed). Patients from both groups also had complete blood count, blood culture, urine analysis, and culture performed. Chest radiography or lumbar puncture could be performed if required. RESULTS: Of the 384 children enrolled and equally randomized into the PCT+ and PCT- groups, 62 (16%) were diagnosed with a serious bacterial infection (urinary tract infection, pneumonia, occult bacteremia, or bacterial meningitis) by primary ED investigation. Ten were also found to be neutropenic (<500 x 10(6)/L). Of the remaining undiagnosed patients, 14 (9%) of 158 received antibiotics in the PCT+ group vs 16 (10%) of 154 in the PCT- group (Delta -2%; 95% confidence interval [CI], -8 to 5). A strategy to treat all patients with PCT of 0.5 ng/mL or greater with prophylactic antibiotic in this group of patients would have resulted in an increase in antibiotic use by 24% (95% CI, 15-33). CONCLUSION: Semiquantitative PCT measurement had no impact on antibiotic use in children aged 1 to 36 months who presented with fever without source. However, a strategy to use prophylactic antibiotics in all patients with abnormal PCT results would have resulted in an increase use of antibiotics.
Keywords Anti-Bacterial Agents/*therapeutic useBacterial Infections/complications/*diagnosis/*drug therapyCalcitonin/*bloodChild, PreschoolCohort StudiesEmergency Service, HospitalFever of Unknown Origin/*blood/etiology/*therapyHospitalizationHumansInfantPredictive Value of TestsProtein Precursors/*bloodReproducibility of ResultsTreatment Outcome
Identifiers
PMID: 20637377
Full text
Structures
Research group Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
Citation
(ISO format)
MANZANO, Sergio et al. Impact of procalcitonin on the management of children aged 1 to 36 months presenting with fever without source: a randomized controlled trial. In: The American Journal of Emergency Medicine, 2010, vol. 28, n° 6, p. 647-653. https://archive-ouverte.unige.ch/unige:21109

229 hits

0 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :