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Title

Hepatitis-associated aplastic anaemia: epidemiology and treatment results obtained in Europe. A report of The EBMT aplastic anaemia working party

Authors
Locasciulli, Anna
Bacigalupo, Andrea
Bruno, Barbara
Montante, Barbara
Marsh, Judith
Tichelli, Andre
Socie, Gerard
Published in British Journal of Haematology. 2010, vol. 149, no. 6, p. 890-895
Abstract In order to assess the epidemiology of Hepatitis-Associated Aplasia (HAA) and compare treatment outcome of HAA with non-HAA patients, we evaluated 3916 aplastic anaemia patients reported to the European Registry between 1990 and 2007. Year, month, season of diagnosis, type and outcome of first-line therapy were analysed. Prevalence of HAA (n = 214) in Europe was 5%. Compared to non-HAA patients, HAA patients were younger (15 vs. 20 years, P < 0.001), with a male prevalence (68% vs. 58% P = 0.002), and were treated earlier after diagnosis (46 vs. 62 d; P < 0.001). No significant differences were found regarding the year or month of diagnosis. No geographic clusters could be identified. Actuarial survival at 10 years after first-line immunosuppression was 69%, and did not differ according to aetiology. The 10-year actuarial survival after transplantation was 70%, and was comparable in HAA and non-HAA patients, when stratified for age and donor type. In a multivariate Cox analysis, increasing age and delayed treatment were significant negative indicators for survival. In conclusion, the incidence of HAA was 5% and was evenly distributed over time and geographic areas in Europe. Treatment outcome and predictive variables, were comparable in patients with or without HAA.
Keywords AdolescentAdultAgedAged, 80 and overAnemia, Aplastic/epidemiology/*etiology/therapyBone Marrow TransplantationChildChild, PreschoolEpidemiologic MethodsEurope/epidemiologyFemaleHepatitis/*complications/epidemiologyHumansImmunosuppressive Agents/therapeutic useInfantMaleMiddle AgedTreatment OutcomeYoung Adult
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PMID: 20456352
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LOCASCIULLI, Anna et al. Hepatitis-associated aplastic anaemia: epidemiology and treatment results obtained in Europe. A report of The EBMT aplastic anaemia working party. In: British Journal of Haematology, 2010, vol. 149, n° 6, p. 890-895. https://archive-ouverte.unige.ch/unige:21089

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Deposited on : 2012-05-23

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