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Scientific article
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Hepatitis-associated aplastic anaemia: epidemiology and treatment results obtained in Europe. A report of The EBMT aplastic anaemia working party

Published inBritish journal of haematology, vol. 149, no. 6, p. 890-895
Publication date2010
Abstract

In order to assess the epidemiology of Hepatitis-Associated Aplasia (HAA) and compare treatment outcome of HAA with non-HAA patients, we evaluated 3916 aplastic anaemia patients reported to the European Registry between 1990 and 2007. Year, month, season of diagnosis, type and outcome of first-line therapy were analysed. Prevalence of HAA (n = 214) in Europe was 5%. Compared to non-HAA patients, HAA patients were younger (15 vs. 20 years, P < 0.001), with a male prevalence (68% vs. 58% P = 0.002), and were treated earlier after diagnosis (46 vs. 62 d; P < 0.001). No significant differences were found regarding the year or month of diagnosis. No geographic clusters could be identified. Actuarial survival at 10 years after first-line immunosuppression was 69%, and did not differ according to aetiology. The 10-year actuarial survival after transplantation was 70%, and was comparable in HAA and non-HAA patients, when stratified for age and donor type. In a multivariate Cox analysis, increasing age and delayed treatment were significant negative indicators for survival. In conclusion, the incidence of HAA was 5% and was evenly distributed over time and geographic areas in Europe. Treatment outcome and predictive variables, were comparable in patients with or without HAA.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia, Aplastic/epidemiology/*etiology/therapy
  • Bone Marrow Transplantation
  • Child
  • Child, Preschool
  • Epidemiologic Methods
  • Europe/epidemiology
  • Female
  • Hepatitis/*complications/epidemiology
  • Humans
  • Immunosuppressive Agents/therapeutic use
  • Infant
  • Male
  • Middle Aged
  • Treatment Outcome
  • Young Adult
Citation (ISO format)
LOCASCIULLI, Anna et al. Hepatitis-associated aplastic anaemia: epidemiology and treatment results obtained in Europe. A report of The EBMT aplastic anaemia working party. In: British journal of haematology, 2010, vol. 149, n° 6, p. 890–895. doi: 10.1111/j.1365-2141.2010.08194.x
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ISSN of the journal0007-1048
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