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Kaposi's sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis

Kostaki, Maria
Pham, Xuan-Cuong
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Published in Dermatology. 2010, vol. 221, no. 4, p. 313-316
Abstract A 63-year-old Swiss patient developed acquired nodules on his right palm after 3 localized surgeries, called 'needle fasciotomy', for Dupuytren's disease. Kaposi's sarcoma (KS) was diagnosed in a biopsy of a nodule. A positive immunolabeling and serology for human herpesvirus 8 has been found, but human immunodeficiency virus and hepatitis C identification remained negative. The nodules were limited to the surgically traumatized area. This first report of a nonimmunocompromised patient developing a KS after repeated surgeries in a unique peculiar localized area with a dense lymphatic network sustains the hypothesis that tissue alterations involving the lymphatic system could play a central role in the occurrence of KS.
Keywords Aminoquinolines/therapeutic useAntineoplastic Agents/therapeutic useBiopsyDupuytren Contracture/immunology/*surgery/virologyHerpesvirus 8, Human/drug effects/immunology/isolation & purificationHumansImmunocompetence/immunologyLymphatic System/drug effects/immunology/virologyMaleMiddle AgedSarcoma, Kaposi/*diagnosis/drug therapy/immunology/pathology/virologySkin Neoplasms/*diagnosis/drug therapy/immunology/virologyTreatment Outcome
PMID: 21051867
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Research groups Anatomie clinique (134)
Groupe Becker Minerva (imagerie ORL) (683)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Rôle du CD44 (809)
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KOSTAKI, Maria et al. Kaposi's sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis. In: Dermatology, 2010, vol. 221, n° 4, p. 313-316. doi: 10.1159/000321193 https://archive-ouverte.unige.ch/unige:21050

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Deposited on : 2012-05-23

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