en
Scientific article
Case report
English

Kaposi's sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis

Published inDermatology, vol. 221, no. 4, p. 313-316
Publication date2010
Abstract

A 63-year-old Swiss patient developed acquired nodules on his right palm after 3 localized surgeries, called 'needle fasciotomy', for Dupuytren's disease. Kaposi's sarcoma (KS) was diagnosed in a biopsy of a nodule. A positive immunolabeling and serology for human herpesvirus 8 has been found, but human immunodeficiency virus and hepatitis C identification remained negative. The nodules were limited to the surgically traumatized area. This first report of a nonimmunocompromised patient developing a KS after repeated surgeries in a unique peculiar localized area with a dense lymphatic network sustains the hypothesis that tissue alterations involving the lymphatic system could play a central role in the occurrence of KS.

Keywords
  • Aminoquinolines/therapeutic use
  • Antineoplastic Agents/therapeutic use
  • Biopsy
  • Dupuytren Contracture/immunology/*surgery/virology
  • Herpesvirus 8, Human/drug effects/immunology/isolation & purification
  • Humans
  • Immunocompetence/immunology
  • Lymphatic System/drug effects/immunology/virology
  • Male
  • Middle Aged
  • Sarcoma, Kaposi/*diagnosis/drug therapy/immunology/pathology/virology
  • Skin Neoplasms/*diagnosis/drug therapy/immunology/virology
  • Treatment Outcome
Citation (ISO format)
KOSTAKI, Maria et al. Kaposi’s sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis. In: Dermatology, 2010, vol. 221, n° 4, p. 313–316. doi: 10.1159/000321193
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ISSN of the journal1018-8665
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