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Determinants of body weight gain and association with neurodevelopmental outcome in infants operated for congenital heart disease

Knirsch, Walter
Bernet, Vera
Balmer, Christian
Dimitropoulos, Anastasia
Bauersfeld, Urs
Latal, Bea
Published in Interactive Cardiovascular and Thoracic Surgery. 2010, vol. 10, no. 3, p. 377-382
Abstract The aim of this prospective study was to examine the determinants of growth failure and the association with neurodevelopmental outcome in infants undergoing open-heart surgery. In 107 infants undergoing open-heart surgery for congenital heart disease (CHD), we evaluated weight at birth, at surgery, and at one year of age (expressed as z-scores). Neurodevelopmental status was assessed before surgery and at one year of age. Median age at surgery was 3.9 months (range: 0.1-10.2). Mean [+/-standard deviation (S.D.)] weight z-score at birth was -0.27 (+/-1.45), before surgery -1.34 (+/-1.45) (P<0.001 vs. birth weight), and at one year -0.86 (+/-1.35), (P<0.001 vs. weight at surgery). Poor preoperative weight (<10th percentile) was associated with genetic disorders [odds ratio (OR) 5.9, P<0.001], preoperative neurological abnormalities (OR 3.41, P<0.05), and older age at surgery (OR 1.01, P<0.05). Weight <10th percentile at one year was associated with the same factors as poor preoperative weight, however, also with risk adjustment for congenital heart surgery-1 (RACHS) score >3 (OR 3.22, P<0.05). Neurodevelopmental outcome at one year was not determined by growth failure. In conclusion, impaired body weight gain before surgery is followed by a catch-up growth after surgery. However, there is no relationship to neurodevelopmental outcome. Genetic comorbidity is the most significant factor for poor weight gain.
Keywords Age FactorsBirth WeightCardiac Surgical Procedures/*adverse effects*Child DevelopmentDevelopmental Disabilities/*etiology/genetics/physiopathologyFemaleGenetic Diseases, Inborn/complications/physiopathologyGrowth Disorders/*etiology/genetics/physiopathologyHeart Defects, Congenital/complications/physiopathology/*surgeryHumansInfantInfant, NewbornLogistic ModelsMaleNervous System/*growth & developmentOdds RatioProspective StudiesRisk AssessmentRisk FactorsTreatment Outcome*Weight Gain/genetics
PMID: 19959555
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Other version: http://icvts.oxfordjournals.org/content/10/3/377.full.pdf
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KNIRSCH, Walter et al. Determinants of body weight gain and association with neurodevelopmental outcome in infants operated for congenital heart disease. In: Interactive Cardiovascular and Thoracic Surgery, 2010, vol. 10, n° 3, p. 377-382. doi: 10.1510/icvts.2009.216135 https://archive-ouverte.unige.ch/unige:21046

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Deposited on : 2012-05-23

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