UNIGE document Scientific Article
previous document  unige:21026  next document
add to browser collection

Estimating attributable mortality due to nosocomial infections acquired in intensive care units

Januel, Jean-Marie
Allard, Robert
Voirin, Nicolas
Lepape, Alain
Allaouchiche, Bernard
Guerin, Claude
Lehot, Jean-Jacques
show hidden authors show all authors [1 - 23]
Published in Infection Control and Hospital Epidemiology. 2010, vol. 31, no. 4, p. 388-394
Abstract BACKGROUND: The strength of the association between intensive care unit (ICU)-acquired nosocomial infections (NIs) and mortality might differ according to the methodological approach taken. OBJECTIVE: To assess the association between ICU-acquired NIs and mortality using the concept of population-attributable fraction (PAF) for patient deaths caused by ICU-acquired NIs in a large cohort of critically ill patients. SETTING: Eleven ICUs of a French university hospital. DESIGN: We analyzed surveillance data on ICU-acquired NIs collected prospectively during the period from 1995 through 2003. The primary outcome was mortality from ICU-acquired NI stratified by site of infection. A matched-pair, case-control study was performed. Each patient who died before ICU discharge was defined as a case patient, and each patient who survived to ICU discharge was defined as a control patient. The PAF was calculated after adjustment for confounders by use of conditional logistic regression analysis. RESULTS: Among 8,068 ICU patients, a total of 1,725 deceased patients were successfully matched with 1,725 control patients. The adjusted PAF due to ICU-acquired NI for patients who died before ICU discharge was 14.6% (95% confidence interval [CI], 14.4%-14.8%). Stratified by the type of infection, the PAF was 6.1% (95% CI, 5.7%-6.5%) for pulmonary infection, 3.2% (95% CI, 2.8%-3.5%) for central venous catheter infection, 1.7% (95% CI, 0.9%-2.5%) for bloodstream infection, and 0.0% (95% CI, -0.4% to 0.4%) for urinary tract infection. CONCLUSIONS: ICU-acquired NI had an important effect on mortality. However, the statistical association between ICU-acquired NI and mortality tended to be less pronounced in findings based on the PAF than in study findings based on estimates of relative risk. Therefore, the choice of methods does matter when the burden of NI needs to be assessed.
Keywords Case-Control StudiesCause of DeathCritical IllnessCross Infection/epidemiology/*mortalityFranceHospital Mortality/*trendsHospitals, UniversityHumansIncidenceIntensive Care Units/*statistics & numerical dataLength of StayPopulation Surveillance/methodsRisk
PMID: 20156064
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.jstor.org/stable/pdfplus/10.1086/650754.pdf
Research group Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
(ISO format)
JANUEL, Jean-Marie et al. Estimating attributable mortality due to nosocomial infections acquired in intensive care units. In: Infection Control and Hospital Epidemiology, 2010, vol. 31, n° 4, p. 388-394. https://archive-ouverte.unige.ch/unige:21026

302 hits

0 download


Deposited on : 2012-05-23

Export document
Format :
Citation style :