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unige:21015 
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Dynamics of dendritic cell-T cell interactions: a role in T cell outcome |
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| Published in | Seminars in Immunopathology. 2010, vol. 32, no. 3, p. 227-238 | |
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Open Access - Licence nationale Springer |
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| Abstract | Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review. | |
| Keywords | Animals — Antigen Presentation — Cell Communication/*immunology — Cell Movement/immunology — Dendritic Cells/*immunology — Humans — Immune Tolerance — Lymph Nodes/cytology/immunology — Lymphocyte Activation — Microscopy, Fluorescence, Multiphoton/methods — Models, Immunological — T-Lymphocytes/*immunology | |
| Identifiers | PMID: 20607241 | |
| Full text |
Article - Free access Other version: http://www.springerlink.com/content/0518lvn7v807275n/fulltext.pdf |
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| Structures | ||
| Research group | Pathologie et immunologie (906) | |
| Citation (ISO format) | HUGUES, Stéphanie. Dynamics of dendritic cell-T cell interactions: a role in T cell outcome. In: Seminars in Immunopathology, 2010, vol. 32, n° 3, p. 227-238. https://archive-ouverte.unige.ch/unige:21015 |
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