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Dynamics of dendritic cell-T cell interactions: a role in T cell outcome

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Published in Seminars in Immunopathology. 2010, vol. 32, no. 3, p. 227-238
Collection Open Access - Licence nationale Springer
Abstract Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review.
Keywords AnimalsAntigen PresentationCell Communication/*immunologyCell Movement/immunologyDendritic Cells/*immunologyHumansImmune ToleranceLymph Nodes/cytology/immunologyLymphocyte ActivationMicroscopy, Fluorescence, Multiphoton/methodsModels, ImmunologicalT-Lymphocytes/*immunology
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PMID: 20607241
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Research group Pathologie et immunologie (906)
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HUGUES, Stéphanie. Dynamics of dendritic cell-T cell interactions: a role in T cell outcome. In: Seminars in Immunopathology, 2010, vol. 32, n° 3, p. 227-238. https://archive-ouverte.unige.ch/unige:21015

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Deposited on : 2012-05-23

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