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Scientific article
Open access
English

Dynamics of dendritic cell-T cell interactions: a role in T cell outcome

ContributorsHugues, Stéphanie
Published inSeminars in immunopathology, vol. 32, no. 3, p. 227-238
Collection
  • Open Access - Licence nationale Springer
Publication date2010
Abstract

Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review.

Keywords
  • Animals
  • Antigen Presentation
  • Cell Communication/*immunology
  • Cell Movement/immunology
  • Dendritic Cells/*immunology
  • Humans
  • Immune Tolerance
  • Lymph Nodes/cytology/immunology
  • Lymphocyte Activation
  • Microscopy, Fluorescence, Multiphoton/methods
  • Models, Immunological
  • T-Lymphocytes/*immunology
Citation (ISO format)
HUGUES, Stéphanie. Dynamics of dendritic cell-T cell interactions: a role in T cell outcome. In: Seminars in immunopathology, 2010, vol. 32, n° 3, p. 227–238. doi: 10.1007/s00281-010-0211-2
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1863-2297
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245downloads

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