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Scientific article
Case report
English

Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man

Published inThe Pediatric infectious disease journal, vol. 29, no. 11, p. 1059-1060
Publication date2010
Abstract

We describe a case of fatal acute disseminated breakthrough toxoplasmosis in a 19-year-old adolescent after haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia despite continued atovaquone prophylaxis. Diagnosis was at necropsy, and confirmed by postmortem polymerase chain reaction analysis in plasma. This report illustrates the need for protozoal monitoring despite atovaquone prophylaxis, in severely immunocompromised patients with intolerance to standard treatment.

Keywords
  • Acute Disease
  • Anti-Infective Agents/therapeutic use
  • *Antibiotic Prophylaxis
  • Atovaquone/*therapeutic use
  • Fatal Outcome
  • Haploidy
  • Hematopoietic Stem Cell Transplantation/*adverse effects
  • Humans
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/surgery
  • Reverse Transcriptase Polymerase Chain Reaction
  • Toxoplasmosis/*diagnosis/etiology/prevention & control
  • Treatment Failure
  • Young Adult
Citation (ISO format)
GARCIA DE LA FUENTE, Isabel et al. Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man. In: The Pediatric infectious disease journal, 2010, vol. 29, n° 11, p. 1059–1060. doi: 10.1097/INF.0b013e3181f30eb6
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ISSN of the journal0891-3668
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