UNIGE document Scientific Article - Case report
previous document  unige:20954  next document
add to browser collection
Title

Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man

Authors
Ansari, Marc
Published in Pediatric Infectious Disease Journal. 2010, vol. 29, no. 11, p. 1059-1060
Abstract We describe a case of fatal acute disseminated breakthrough toxoplasmosis in a 19-year-old adolescent after haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia despite continued atovaquone prophylaxis. Diagnosis was at necropsy, and confirmed by postmortem polymerase chain reaction analysis in plasma. This report illustrates the need for protozoal monitoring despite atovaquone prophylaxis, in severely immunocompromised patients with intolerance to standard treatment.
Keywords Acute DiseaseAnti-Infective Agents/therapeutic use*Antibiotic ProphylaxisAtovaquone/*therapeutic useFatal OutcomeHaploidyHematopoietic Stem Cell Transplantation/*adverse effectsHumansMalePrecursor Cell Lymphoblastic Leukemia-Lymphoma/surgeryReverse Transcriptase Polymerase Chain ReactionToxoplasmosis/*diagnosis/etiology/prevention & controlTreatment FailureYoung Adult
Identifiers
PMID: 20724953
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Posfay-Barbe Clara (pédiatrie générale) (853)
Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
Citation
(ISO format)
GARCIA DE LA FUENTE, Isabel et al. Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man. In: Pediatric Infectious Disease Journal, 2010, vol. 29, n° 11, p. 1059-1060. https://archive-ouverte.unige.ch/unige:20954

273 hits

0 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :