en
Scientific article
English

Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study

Published inBritish journal of cancer, vol. 103, no. 3, p. 416-422
Publication date2010
Abstract

BACKGROUND: The advent of highly active antiretroviral therapy (HAART) in 1996 led to a decrease in the incidence of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), but not of other cancers, among people with HIV or AIDS (PWHA). It also led to marked increases in their life expectancy. METHODS: We conducted a record-linkage study between the Swiss HIV Cohort Study and nine Swiss cantonal cancer registries. In total, 9429 PWHA provided 20,615, 17,690, and 15,410 person-years in the pre-, early-, and late-HAART periods, respectively. Standardised incidence ratios in PWHA vs the general population, as well as age-standardised, and age-specific incidence rates were computed for different periods. RESULTS: Incidence of KS and NHL decreased by several fold between the pre- and early-HAART periods, and additionally declined from the early- to the late-HAART period. Incidence of cancers of the anus, liver, non-melanomatous skin, and Hodgkin's lymphoma increased in the early- compared with the pre-HAART period, but not during the late-HAART period. The incidence of all non-AIDS-defining cancers (NADCs) combined was similar in all periods, and approximately double that in the general population. CONCLUSIONS: Increases in the incidence of selected NADCs after the introduction of HAART were largely accounted for by the ageing of PWHA.

Keywords
  • Acquired Immunodeficiency Syndrome/drug therapy
  • Adult
  • Aged
  • Antiretroviral Therapy, Highly Active/*adverse effects
  • Chromosome Mapping
  • Cohort Studies
  • Drug Administration Schedule
  • Female
  • HIV Infections/drug therapy
  • Humans
  • Incidence
  • Lymphoma, Non-Hodgkin/*epidemiology
  • Male
  • Middle Aged
  • Neoplasms/*epidemiology
  • Sarcoma, Kaposi/epidemiology
  • Skin Neoplasms/epidemiology
  • Switzerland/epidemiology
Research group
Citation (ISO format)
FRANCESCHI, S. et al. Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study. In: British journal of cancer, 2010, vol. 103, n° 3, p. 416–422. doi: 10.1038/sj.bjc.6605756
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ISSN of the journal0007-0920
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