Osteoarthritis: Small studies overestimate the benefit of therapies for OA

Finckh, Axel; Tramer, Martin

doi:10.1038/nrrheum.2010.162

Scientific article

English

Osteoarthritis: Small studies overestimate the benefit of therapies for OA

ContributorsFinckh, Axel

; Tramer, Martin

Published inNature reviews. Rheumatology, vol. 6, no. 11, p. 617-618

Publication date2010

Abstract

A meta-epidemiological study has revealed that the inclusion of small studies in meta-analyses of osteoarthritis interventions could lead to an overestimation of the benefit of these interventions. Does this mean meta-analyses should be restricted to trials with large sample sizes?

Keywords

Humans
Meta-Analysis as Topic
Osteoarthritis/therapy
Publication Bias
Randomized Controlled Trials as Topic
Reproducibility of Results
Sample Size
Treatment Outcome

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Citation (ISO format)

FINCKH, Axel, TRAMER, Martin. Osteoarthritis: Small studies overestimate the benefit of therapies for OA. In: Nature reviews. Rheumatology, 2010, vol. 6, n° 11, p. 617–618. doi: 10.1038/nrrheum.2010.162

Article (Published version)

Identifiers

PID : unige:20935
DOI : 10.1038/nrrheum.2010.162
PMID : 21037558

Journal ISSN1759-4790

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Osteoarthritis: Small studies overestimate the benefit of therapies for OA

A meta-epidemiological study has revealed that the inclusion of small studies in meta-analyses of osteoarthritis interventions could lead to an overestimation of the benefit of these interventions. Does this mean meta-analyses should be restricted to trials with large sample sizes?

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