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Osteoarthritis: Small studies overestimate the benefit of therapies for OA

Published in Nature reviews. Rheumatology. 2010, vol. 6, no. 11, p. 617-618
Abstract a meta-epidemiological study has revealed that the inclusion of small studies in meta-analyses of osteoarthritis interventions could lead to an overestimation of the benefit of these interventions. Does this mean meta-analyses should be restricted to trials with large sample sizes?
Keywords Humans*Meta-Analysis as TopicOsteoarthritis/*therapyPublication Bias*Randomized Controlled Trials as TopicReproducibility of ResultsSample SizeTreatment Outcome
PMID: 21037558
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Research groups La Médecine Périopératoire et l'anesthésie (70)
Mécanisme de l'inflammation articulaire (44)
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FINCKH, Axel, TRAMER, Martin. Osteoarthritis: Small studies overestimate the benefit of therapies for OA. In: Nature reviews. Rheumatology, 2010, vol. 6, n° 11, p. 617-618. doi: 10.1038/nrrheum.2010.162 https://archive-ouverte.unige.ch/unige:20935

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Deposited on : 2012-05-23

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