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Scientific article
English

Extraosseous langerhans cell histiocytosis in children

Contributors

Schmidt, Sabine; Eich, Georg; Geoffray, Anne; Hanquinet, Sylviane; Waibel, Peter; Wolf, Rainer; Letovanec, Igor; Alamo-Maestre, Leonore; Gudinchet, Francois

Published in

Radiographics, vol. 28, no. 3, p. 707-726

Publication date

2008

Abstract

Langerhans cell histiocytosis, a rare disease that occurs mainly in children, may produce a broad range of manifestations, from a single osseous lesion to multiple lesions involving more than one organ or system. The clinical course varies widely in relation to the patient's age. Multisystem disease may demonstrate especially aggressive behavior in very young children, with the outcome depending largely on the stage of disease and the degree of related organ dysfunction at the time of diagnosis. Extraosseous manifestations are less commonly seen than osseous ones and may be more difficult to identify. To accurately detect extraosseous Langerhans cell histiocytosis at an early stage, radiologists must recognize the significance of individual clinical and laboratory findings as well as the relevance of imaging features for the differential diagnosis. The pattern and severity of pulmonary, thymic, hepatobiliary, splenic, gastrointestinal, neurologic, mucocutaneous, soft-tissue (head and neck), and salivary involvement in Langerhans cell histiocytosis generally are well depicted with conventional radiography, ultrasonography, computed tomography, and magnetic resonance imaging. However, the imaging features are not pathognomonic, and a biopsy usually is necessary to establish a definitive diagnosis.

Keywords

  • Child, Preschool
  • Diagnostic Imaging/methods
  • Female
  • Histiocytosis, Langerhans-Cell/diagnosis
  • Humans
  • Image Enhancement/methods
  • Male
  • Multiple Organ Failure/diagnosis

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

SCHMIDT, Sabine et al. Extraosseous langerhans cell histiocytosis in children. In: Radiographics, 2008, vol. 28, n° 3, p. 707–726. doi: 10.1148/rg.283075108

Main files (1)

Article (Accepted version)

Identifiers

Additional URL for this publication

http://radiographics.rsnajnls.org/cgi/content/full/28/3/707

Journal ISSN

0271-5333
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3downloads

Technical informations

Creation

18/06/2009 14:11:00

First validation

18/06/2009 14:11:00

Update

14/03/2023 15:08:59

Status update

14/03/2023 15:08:59

Last indexation

29/10/2024 11:45:14
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