Scientific article
English

HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

Published inJournal of leukocyte biology, vol. 87, no. 2, p. 223-235
Publication date2010
Abstract

Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threatening infections and is associated with organ toxicity when used long-term. Thus, alternative approaches that inhibit only the unwanted immune responses and preserve general immunity are highly desirable. The receptor/ligand pairs involved in the cross-talk between DC and T cells have been the focus of intense and exciting research during the last decade. The HVEM/LIGHT/BTLA/CD160 costimulatory/coinhibitory pathway has emerged as a potential target for the development of immune therapeutic interventions. Herein, we will summarize and discuss how blockade of the costimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.

Keywords
  • Animals
  • Antigens, CD/ immunology
  • Autoimmune Diseases/immunology/therapy
  • GPI-Linked Proteins
  • Graft Rejection/immunology/therapy
  • Humans
  • Receptors, Immunologic/ immunology
  • Receptors, Tumor Necrosis Factor, Member 14/ immunology
  • Signal Transduction/ immunology
  • Tumor Necrosis Factor Ligand Superfamily Member 14/ immunology
Citation (ISO format)
DEL RIO, M. L. et al. HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation. In: Journal of leukocyte biology, 2010, vol. 87, n° 2, p. 223–235. doi: 10.1189/jlb.0809590
Main files (1)
Article
accessLevelRestricted
Identifiers
Additional URL for this publicationhttp://www.jleukbio.org/content/87/2/223.full
Journal ISSN0741-5400
534views
0downloads

Technical informations

Creation23/05/2012 08:45:09
First validation23/05/2012 08:45:09
Update time14/03/2023 17:32:38
Status update14/03/2023 17:32:38
Last indexation29/10/2024 19:58:52
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack