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HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

del Rio, M. L.
Lucas, C. L.
Rayat, G.
Rodriguez-Barbosa, J. I.
Published in Journal of Leukocyte Biology. 2010, vol. 87, no. 2, p. 223-235
Abstract Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threatening infections and is associated with organ toxicity when used long-term. Thus, alternative approaches that inhibit only the unwanted immune responses and preserve general immunity are highly desirable. The receptor/ligand pairs involved in the cross-talk between DC and T cells have been the focus of intense and exciting research during the last decade. The HVEM/LIGHT/BTLA/CD160 costimulatory/coinhibitory pathway has emerged as a potential target for the development of immune therapeutic interventions. Herein, we will summarize and discuss how blockade of the costimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.
Keywords AnimalsAntigens, CD/ immunologyAutoimmune Diseases/immunology/therapyGPI-Linked ProteinsGraft Rejection/immunology/therapyHumansReceptors, Immunologic/ immunologyReceptors, Tumor Necrosis Factor, Member 14/ immunologySignal Transduction/ immunologyTumor Necrosis Factor Ligand Superfamily Member 14/ immunology
PMID: 20007250
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Other version: http://www.jleukbio.org/content/87/2/223.full
Research group Cultures cellulaires et transplantations (519)
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DEL RIO, M. L. et al. HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation. In: Journal of Leukocyte Biology, 2010, vol. 87, n° 2, p. 223-235. https://archive-ouverte.unige.ch/unige:20887

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Deposited on : 2012-05-23

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