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An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship

de Brito, Olga Martins
Published in EMBO Journal. 2010, vol. 29, no. 16, p. 2715-2723
Abstract Organelle localization is often crucial to properly modulate cellular functions and signalling cascades. For example, the distribution of organelles in axons is crucial for their function and is dysregulated in several diseases. Similarly, relative positioning of two or more organelles is also important to perform certain specialized processes. Perhaps, the best-known form of interorganellar organization is that between endoplasmic reticulum (ER) and mitochondria. Close communication between these two compartments has been observed for a long time. Recent evidence suggests that this is the basis for a bidirectional communication regulating a number of physiological processes ranging from mitochondrial energy and lipid metabolism to Ca(2+) signalling and cell death. The recent discovery of some of the molecular mediators of the tethering already allowed to extend the function of this paradigmatic spatial organization to previously unexpected functions, and will foster future research to explore it in cellular signalling cascades as well as in disease.
Keywords AnimalsCalcium/metabolismCell DeathEndoplasmic Reticulum/*metabolismHumansMitochondria/*metabolism*Signal Transduction
PMID: 20717141
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Research group Les mitochondries dans la vie cellulaire (850)
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DE BRITO, Olga Martins, SCORRANO, Luca. An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. In: EMBO Journal, 2010, vol. 29, n° 16, p. 2715-2723. doi: 10.1038/emboj.2010.177 https://archive-ouverte.unige.ch/unige:20878

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Deposited on : 2012-05-23

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