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Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture

Published in Clinical Nutrition. 2010, vol. 29, no. 1, p. 78-83
Abstract BACKGROUND & AIMS: In patients with recent hip fracture, reduced serum IGF-I in relation to protein undernutrition is frequent. Elevation of circulating IGF-I in response to a daily oral supplement of 20 g of casein was observed after 6 months. This study determined if the response to casein as compared to whey protein can be observed as early as after one week. METHODS: 45 women were randomized after recent hip fracture in 3 groups receiving a preparation of 20 g of casein, an isocaloric supplement of 20 g of whey protein or an isocaloric supplement of 15 g of whey protein combined with 5 g of essential amino acids (a.a.). RESULTS: A similar significant elevation of serum IGF-I was already observed after 7 days for casein (+37.3 microg/L), whey (+29.4) and for whey+a.a. (+34.3). From day 7-28, no further significant rise in IGF-I was recorded. CONCLUSION: After one week of protein supplementation, the percent increase of IGF-I was of similar magnitude to that previously observed after 6 months of protein supplementation. It suggests that in hip fracture patients, long-term effects of various protein preparations on IGF-I could be predicted from changes observed as early as 7 days after the onset of supplementation.
Keywords Administration, OralAged, 80 and overAlbumins/drug effectsAmino Acids, Essential/administration & dosage/blood/therapeutic useAnalysis of VarianceBiological Markers/bloodCaseins/administration & dosage/blood/therapeutic useDietary Proteins/administration & dosage/blood/ therapeutic useDietary SupplementsFemaleFollow-Up StudiesGeriatric Assessment/methodsHip Fractures/ blood/complicationsHumansInsulin-Like Growth Factor I/drug effects/ metabolismMilk Proteins/administration & dosage/blood/therapeutic usePrealbumin/drug effectsProtein-Energy Malnutrition/ diet therapy/etiology
PMID: 19660844
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Other version: http://www.sciencedirect.com/science/journal/02615614
Research groups Nutrition et os (66)
Chirurgie orthopédique et traumatologique (98)
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CHEVALLEY, Thierry et al. Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture. In: Clinical Nutrition, 2010, vol. 29, n° 1, p. 78-83. doi: 10.1016/j.clnu.2009.07.003 https://archive-ouverte.unige.ch/unige:20844

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Deposited on : 2012-05-23

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