en
Scientific article
Review
French

Erythropoietine et neuroprotection

Other titleErythropoietin and neuroprotection
Published inArchives de pédiatrie, vol. 17 Suppl 3, p. S78-84
Publication date2010
Abstract

Erythropoietin (Epo) has long been recognised for its role in the control of erythropoiesis and therefore in the treatment of anemia including anemia of prematurity. The erythropoietin receptor (Epo-R) though is expressed in many other organs including the CNS. This review focuses on the role of erythropoietin during the development of the CNS and its potential role as a neuroprotective agent. Epo-R is expressed in many different cellules of the CNS during development including neural progenitor cells, neurons, astrocytes and oligodendrocytes. In the event of hypoxia CNS cells respond with increase of erythropoietin release with subsequent stimulation of neurogenesis through Epo-R on neural progenitor cells. In an Epo-R knock-out model therefore cerebral development is severely impaired. In models of hypoxia-ischemia exogenous Epo has been shown to reduce lesion size and improve structural and functional recovery. Human studies are emerging using Epo as a neuroprotective agent both for the term infant with hypoxia-ischemia as well as for the extremely preterm infant.

Keywords
  • Brain/growth & development
  • Erythropoietin/*therapeutic use
  • Gene Knockout Techniques
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases/*drug therapy/genetics
  • Neuroprotective Agents/therapeutic use
  • Receptors, Erythropoietin/deficiency/genetics/physiology
Citation (ISO format)
CHATAGNER, Alexandra et al. Erythropoietine et neuroprotection. In: Archives de pédiatrie, 2010, vol. 17 Suppl 3, p. S78–84. doi: 10.1016/S0929-693X(10)70905-2
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ISSN of the journal0929-693X
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