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Title

Language and motor skills are impaired in infants with biliary atresia before transplantation
Authors
Caudle, Susan E.
Katzenstein, Jennifer M.
Karpen, Saul J.
Mclin, Valérie Anne
Published in Journal of Pediatrics. 2010, vol. 156, no. 6, p. 936-940, 940 e931
Abstract OBJECTIVE: To test the hypothesis that in very young patients with biliary atresia, cognitive deficits are apparent before transplantation. STUDY DESIGN: With the Mullen Scales of Early Learning (Mullen), we examined 15 infants (mean age, 7.8 months) with biliary atresia, correlating Mullen scores with standard clinical and biochemical parameters. RESULTS: Overall, participants displayed significant delays in gross motor and language skills, and fine motor and visual reasoning skills were relatively preserved. The international normalized ratio correlated inversely with gross (P < .01) and fine (P < .05) motor skills. Growth parameters correlated positively with expressive language ability, but length of hospitalization and mode of feeding did not. Age at performance of the Kasai procedure was found to correlate with receptive language performance (P < .05). CONCLUSIONS: Very young children with biliary atresia display a characteristic profile of early developmental deficits before transplantation. These findings suggest that early intervention and aggressive nutritional management should be the standard of care to minimize neurocognitive effects.
Keywords Biliary Atresia/*epidemiology/surgery — Cognition Disorders/epidemiology — Energy Intake — Female — Humans — Infant — International Normalized Ratio — Language Development Disorders/*epidemiology — Liver Transplantation — Male — *Motor Skills — Problem Solving — Thinking
Identifiers
PMID: 20223479
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Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Développement du tube digestif chez les vertébrés (900)
Citation
(ISO format) 		CAUDLE, Susan E. et al. Language and motor skills are impaired in infants with biliary atresia before transplantation. In: Journal of Pediatrics, 2010, vol. 156, n° 6, p. 936-940, 940 e931. https://archive-ouverte.unige.ch/unige:20828

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Deposited on : 2012-05-23

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