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Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

Castanier, Celine
Vazquez, Aime
Arnoult, Damien
Published in EMBO Reports. 2010, vol. 11, no. 2, p. 133-138
Abstract The intracellular retinoic acid-inducible gene I-like receptors (RLRs) sense viral ribonucleic acid and signal through the mitochondrial protein mitochondrial antiviral signalling (MAVS) to trigger the production of type I interferons and proinflammatory cytokines. In this study, we report that RLR activation promotes elongation of the mitochondrial network. Mimicking this elongation enhances signalling downstream from MAVS and favours the binding of MAVS to stimulator of interferon genes, an endoplasmic reticulum (ER) protein involved in the RLR pathway. By contrast, enforced mitochondrial fragmentation dampens signalling and reduces the association between both proteins. Our finding that MAVS is associated with a pool of mitofusin 1, a protein of the mitochondrial fusion machinery, suggests that MAVS is capable of regulating mitochondrial dynamics to facilitate the mitochondria-ER association required for signal transduction. Importantly, we observed that viral mitochondria-localized inhibitor of apoptosis, a cytomegalovirus (CMV) antiapoptotic protein that promotes mitochondrial fragmentation, inhibits signalling downstream from MAVS, suggesting a possible new immune modulation strategy of the CMV.
Keywords Antiviral Agents/*metabolismCells, CulturedHeLa CellsHumansImmunity, Innate/*physiologyMembrane Proteins/metabolismMitochondria/immunology/*metabolism/*physiologyMitochondrial Proteins/metabolismOrganelle Shape/immunologyOrganelle Size/immunologyProtein BindingReceptors, Retinoic Acid/metabolism/*physiologySignal Transduction/immunologyVirus Diseases/immunology/metabolism
PMID: 20019757
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Research group Virologie moléculaire (275)
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CASTANIER, Celine et al. Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway. In: EMBO Reports, 2010, vol. 11, n° 2, p. 133-138. doi: 10.1038/embor.2009.258 https://archive-ouverte.unige.ch/unige:20825

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Deposited on : 2012-05-23

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