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Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer |
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Published in | European Journal of Medicinal Chemistry. 2010, vol. 45, no. 11, p. 5465-5467 | |
Abstract | In the aim to find new radiotracers for the in vivo imaging of 5-HT(4) receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT(4) ligand using an iododestannylation procedure. The [(125)I]-ligand was obtained in a high radiochemical yield. Preliminary autoradiographic and ex vivo studies failed to show a specific labeling of 5-HT(4) receptors. | |
Keywords | Chromatography, High Pressure Liquid — Iodine Radioisotopes/*chemistry/*diagnostic use — Magnetic Resonance Spectroscopy — Pyrazines/*chemical synthesis/*diagnostic use — Pyrroles/*chemical synthesis/*diagnostic use — Thiophenes/*chemical synthesis/*diagnostic use — *Tomography, Emission-Computed, Single-Photon | |
Identifiers | PMID: 20817325 | |
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Research group | Neuroimagerie moléculaire en psychiatrie (983) | |
Citation (ISO format) | CAILLY, Thomas et al. Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. In: European Journal of Medicinal Chemistry, 2010, vol. 45, n° 11, p. 5465-5467. doi: 10.1016/j.ejmech.2010.07.052 https://archive-ouverte.unige.ch/unige:20817 |