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Scientific article
English

Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer

Published inEuropean journal of medicinal chemistry, vol. 45, no. 11, p. 5465-5467
Publication date2010
Abstract

In the aim to find new radiotracers for the in vivo imaging of 5-HT(4) receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT(4) ligand using an iododestannylation procedure. The [(125)I]-ligand was obtained in a high radiochemical yield. Preliminary autoradiographic and ex vivo studies failed to show a specific labeling of 5-HT(4) receptors.

Keywords
  • Chromatography, High Pressure Liquid
  • Iodine Radioisotopes/*chemistry/*diagnostic use
  • Magnetic Resonance Spectroscopy
  • Pyrazines/*chemical synthesis/*diagnostic use
  • Pyrroles/*chemical synthesis/*diagnostic use
  • Thiophenes/*chemical synthesis/*diagnostic use
  • *Tomography, Emission-Computed, Single-Photon
Citation (ISO format)
CAILLY, Thomas et al. Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. In: European journal of medicinal chemistry, 2010, vol. 45, n° 11, p. 5465–5467. doi: 10.1016/j.ejmech.2010.07.052
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