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Titles listSynthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation...
Titles listSynthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation...
Scientific Article
unige:20817 
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Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer |
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| Authors | ||
| Published in | European Journal of Medicinal Chemistry. 2010, vol. 45, no. 11, p. 5465-5467 | |
| Abstract | In the aim to find new radiotracers for the in vivo imaging of 5-HT(4) receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT(4) ligand using an iododestannylation procedure. The [(125)I]-ligand was obtained in a high radiochemical yield. Preliminary autoradiographic and ex vivo studies failed to show a specific labeling of 5-HT(4) receptors. | |
| Keywords | Chromatography, High Pressure Liquid — Iodine Radioisotopes/*chemistry/*diagnostic use — Magnetic Resonance Spectroscopy — Pyrazines/*chemical synthesis/*diagnostic use — Pyrroles/*chemical synthesis/*diagnostic use — Thiophenes/*chemical synthesis/*diagnostic use — *Tomography, Emission-Computed, Single-Photon | |
| Identifiers | PMID: 20817325 | |
| Full text |
Article - Limited access to UNIGE Other version: http://ac.els-cdn.com/S0223523410005489/1-s2.0-S0223523410005489-main.pdf?_tid=77fedae6e3d9dd6fee42f572b2ea4fcd&acdna... |
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| Structures | ||
| Research group | Neuroimagerie moléculaire en psychiatrie (983) | |
| Citation (ISO format) | CAILLY, Thomas et al. Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. In: European Journal of Medicinal Chemistry, 2010, vol. 45, n° 11, p. 5465-5467. doi: 10.1016/j.ejmech.2010.07.052 https://archive-ouverte.unige.ch/unige:20817 |
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