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Title

Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer
Authors
Cailly, Thomas
Dumas, Noe
Millet, Philippe
Lemaitre, Stephane
Fabis, Frederic
Charnay, Yves
Rault, Sylvain
Published in European Journal of Medicinal Chemistry. 2010, vol. 45, no. 11, p. 5465-5467
Abstract In the aim to find new radiotracers for the in vivo imaging of 5-HT(4) receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT(4) ligand using an iododestannylation procedure. The [(125)I]-ligand was obtained in a high radiochemical yield. Preliminary autoradiographic and ex vivo studies failed to show a specific labeling of 5-HT(4) receptors.
Keywords Chromatography, High Pressure Liquid — Iodine Radioisotopes/*chemistry/*diagnostic use — Magnetic Resonance Spectroscopy — Pyrazines/*chemical synthesis/*diagnostic use — Pyrroles/*chemical synthesis/*diagnostic use — Thiophenes/*chemical synthesis/*diagnostic use — *Tomography, Emission-Computed, Single-Photon
Identifiers
PMID: 20817325
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Other version: http://ac.els-cdn.com/S0223523410005489/1-s2.0-S0223523410005489-main.pdf?_tid=77fedae6e3d9dd6fee42f572b2ea4fcd&acdna...
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group Neuroimagerie moléculaire en psychiatrie (983)
Citation
(ISO format) 		CAILLY, Thomas et al. Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. In: European Journal of Medicinal Chemistry, 2010, vol. 45, n° 11, p. 5465-5467. https://archive-ouverte.unige.ch/unige:20817

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Deposited on : 2012-05-23

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