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Title

Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer

Authors
Cailly, Thomas
Lemaitre, Stephane
Fabis, Frederic
Rault, Sylvain
Published in European Journal of Medicinal Chemistry. 2010, vol. 45, no. 11, p. 5465-5467
Abstract In the aim to find new radiotracers for the in vivo imaging of 5-HT(4) receptors by ultra-high resolution quantitative SPECT, we have developed the synthesis of a radioiodinated 5-HT(4) ligand using an iododestannylation procedure. The [(125)I]-ligand was obtained in a high radiochemical yield. Preliminary autoradiographic and ex vivo studies failed to show a specific labeling of 5-HT(4) receptors.
Keywords Chromatography, High Pressure LiquidIodine Radioisotopes/*chemistry/*diagnostic useMagnetic Resonance SpectroscopyPyrazines/*chemical synthesis/*diagnostic usePyrroles/*chemical synthesis/*diagnostic useThiophenes/*chemical synthesis/*diagnostic use*Tomography, Emission-Computed, Single-Photon
Identifiers
PMID: 20817325
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Research group Neuroimagerie moléculaire en psychiatrie (983)
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(ISO format)
CAILLY, Thomas et al. Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. In: European Journal of Medicinal Chemistry, 2010, vol. 45, n° 11, p. 5465-5467. https://archive-ouverte.unige.ch/unige:20817

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Deposited on : 2012-05-23

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