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Vascular invasion in pancreatic cancer: Imaging modalities, preoperative diagnosis and surgical management

Chilcott, Michael
Published in World Journal of Gastroenterology. 2010, vol. 16, no. 7, p. 818-831
Abstract Pancreatic cancer is associated with a poor prognosis, and surgical resection remains the only chance for curative therapy. In the absence of metastatic disease, which would preclude resection, assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer. A frequent error is to misdiagnose an involved major vessel. Obviously, surgical exploration with pathological examination remains the "gold standard" in terms of evaluation of resectability, especially from the point of view of vascular involvement. However, current imaging modalities have improved and allow detection of vascular invasion with more accuracy. A venous resection in pancreatic cancer is a feasible technique and relatively reliable. Nevertheless, a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion. Although the discovery of an arterial invasion during the operation might require an aggressive management, discovery before the operation should be considered as a contraindication. Detection of vascular invasion remains one of the most important challenges in pancreatic surgery. The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer.
Keywords Blood Vessels/ pathologyDiagnostic Imaging/methodsEndosonographyHumansMagnetic Resonance ImagingNeoplasm InvasivenessPancreatectomy/adverse effects/mortalityPancreatic Neoplasms/ diagnosis/mortality/pathology/surgeryPatient SelectionPositron-Emission TomographyPredictive Value of TestsPreoperative CareTime FactorsTomography, X-Ray ComputedTreatment OutcomeUltrasonography, InterventionalVascular Surgical Procedures/adverse effects/mortality
PMID: 20143460
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Other version: http://www.wjgnet.com/1007-9327/index.jsp
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
Radiologie des urgences (800)
(ISO format)
BUCHS, Nicolas et al. Vascular invasion in pancreatic cancer: Imaging modalities, preoperative diagnosis and surgical management. In: World Journal of Gastroenterology, 2010, vol. 16, n° 7, p. 818-831. https://archive-ouverte.unige.ch/unige:20815

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Deposited on : 2012-05-23

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