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Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer |
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Published in | World Journal of Gastroenterology. 2010, vol. 16, no. 7, p. 868-874 | |
Abstract | AIM: To investigate feasibility, morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer. METHODS: Patients suffering from locally-advanced (T3-4 any N M0 or any T N1-3 M0) gastric carcinoma, staged with endoscopic ultrasound, bone scan, computed tomography, and laparoscopy, were assigned to receive four 21 d/cycles of TCF (docetaxel 75 mg/m(2) day 1, cisplatin 75 mg/m(2) day 1, and fluorouracil 300 mg/m(2) per day for days 1-14), either before (Arm A) or after (Arm B) gastrectomy. Operative morbidity, overall mortality, and severe adverse events were compared by intention-to-treat analysis. RESULTS: From November 1999 to November 2005, 70 patients were treated. After preoperative TCF (Arm A), thirty-two (94%) resections were performed, 85% of which were R0. Pathological response was complete in 4 patients (11.7%), and partial in 18 (55%). No surgical mortality and 28.5% morbidity rate were observed, similar to those of immediate surgery arm (P = 0.86). Serious chemotherapy adverse events tended to be more frequent in arm B (23% vs 11%, P = 0.07), with a single death per arm. CONCLUSION: Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | |
Keywords | Adult — Aged — Antineoplastic Combined Chemotherapy Protocols/adverse effects/ therapeutic use — Carcinoma/ drug therapy/mortality/pathology/ surgery — Chemotherapy, Adjuvant — Cisplatin/administration & dosage — Disease-Free Survival — Endosonography — Europe — Feasibility Studies — Female — Fluorouracil/administration & dosage — Gastrectomy/adverse effects/mortality — Humans — Laparoscopy — Male — Middle Aged — Neoadjuvant Therapy — Neoplasm Invasiveness — Neoplasm Staging — Radionuclide Imaging — Stomach Neoplasms/ drug therapy/mortality/pathology/ surgery — Taxoids/administration & dosage — Time Factors — Tomography, Spiral Computed — Treatment Outcome | |
Identifiers | PMID: 20143466 | |
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Research group | Groupe Roth Arnaud (oncologie) (285) | |
Citation (ISO format) | BIFFI, Roberto et al. Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer. In: World Journal of Gastroenterology, 2010, vol. 16, n° 7, p. 868-874. https://archive-ouverte.unige.ch/unige:20779 |