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Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens

Bartholomay, Lyric C.
Mayhew, George F.
Campbell, Corey L.
Michel, Kristin
Zou, Zhen
Ramirez, Jose L.
Das, Suchismita
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Published in Science. 2010, vol. 330, no. 6000, p. 88-90
Abstract The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
Keywords Aedes/genetics/immunology/microbiology/parasitologyAnimalsAnopheles gambiae/genetics/metabolism/microbiology/parasitologyArboviruses/immunology/pathogenicity/physiologyBacteria/immunology/pathogenicityBiological EvolutionCulex/*genetics/*immunology/microbiology/parasitologyEcosystemFilarioidea/immunology/pathogenicity/physiologyGene Expression ProfilingGene Expression Regulation*Genes, Insect*Host-Pathogen InteractionsImmunity, Innate/*geneticsInsect Vectors/*genetics/*immunology/microbiology/parasitologyOligonucleotide Array Sequence AnalysisPhylogenyRNA InterferenceTranscription, GeneticWest Nile virus/immunology/pathogenicity/physiology
PMID: 20929811
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Other version: http://www.sciencemag.org/content/330/6000/88.full.pdf
Research group Génomique Evolutionnaire Computationnelle (830)
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BARTHOLOMAY, Lyric C. et al. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. In: Science, 2010, vol. 330, n° 6000, p. 88-90. doi: 10.1126/science.1193162 https://archive-ouverte.unige.ch/unige:20761

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Deposited on : 2012-05-23

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