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Antiepileptic drugs modify power of high EEG frequencies and their neural generators

Brunet, D.
Kaplan, P. W.
Published in European Journal of Neurology. 2010, vol. 17, no. 10, p. 1308-1312
Abstract BACKGROUND: The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology. METHODS: Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, arbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group. RESULTS: Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions. CONCLUSION: Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.
Keywords AdolescentAdultAnticonvulsants/*pharmacologyBrain Waves/*drug effects/physiologyCarbamazepine/pharmacologyElectroencephalography/*drug effectsEpilepsy/*drug therapy/*pathology/physiopathologyFemaleHumansIon Channels/drug effects/physiologyMaleNeurons/drug effects/*pathologyTriazines/pharmacologyValproic Acid/pharmacologyYoung Adult
PMID: 20402743
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Research groups Organisation et plasticité des réseaux neuronaux cérébraux (148)
Epilepsie et Chirurgie (149)
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ARZY, Shahar et al. Antiepileptic drugs modify power of high EEG frequencies and their neural generators. In: European Journal of Neurology, 2010, vol. 17, n° 10, p. 1308-1312. https://archive-ouverte.unige.ch/unige:20746

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Deposited on : 2012-05-23

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