UNIGE document Scientific Article - Case report
previous document  unige:20742  next document
add to browser collection
Title

Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations
Authors
Ansermet, François
Lespinasse, James
Gimelli, Stefania
Bena, Frédérique
Giacobino, Ariane
Published in Journal of Child Sexual Abuse. 2010, vol. 19, no. 3, p. 337-344
Abstract We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account.
Keywords Adolescent — Adult — Child Abuse, Sexual/*psychology — *Chromosome Deletion — Chromosomes, Human, Pair 6/*genetics — Craniofacial Abnormalities/genetics/psychology — Domestic Violence/psychology — *Father-Child Relations — Female — Heterozygote Detection — Humans — *Inbreeding — Incest/*psychology — Intellectual Disability/*genetics/*psychology — Intercellular Signaling Peptides and Proteins/*genetics — Pedigree — Phenotype — Pregnancy — Self Concept — *Social Environment
Identifiers
PMID: 20509080
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.tandfonline.com/doi/pdf/10.1080/10538711003788991
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research groups Groupe Ansermet François (psychiatrie) (861)
Groupe Giacobino Ariane (génétique) (923)
Citation
(ISO format) 		ANSERMET, François et al. Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. In: Journal of Child Sexual Abuse, 2010, vol. 19, n° 3, p. 337-344. https://archive-ouverte.unige.ch/unige:20742

254 hits

0 download

Contact an author

Update request

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :