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Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations

Lespinasse, James
Bena, Frédérique
Published in Journal of child sexual abuse. 2010, vol. 19, no. 3, p. 337-344
Abstract We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account.
Keywords AdolescentAdultChild Abuse, Sexual/*psychology*Chromosome DeletionChromosomes, Human, Pair 6/*geneticsCraniofacial Abnormalities/genetics/psychologyDomestic Violence/psychology*Father-Child RelationsFemaleHeterozygote DetectionHumans*InbreedingIncest/*psychologyIntellectual Disability/*genetics/*psychologyIntercellular Signaling Peptides and Proteins/*geneticsPedigreePhenotypePregnancySelf Concept*Social Environment
PMID: 20509080
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Research groups Groupe Ansermet François (psychiatrie) (861)
Groupe Giacobino Ariane (génétique) (923)
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ANSERMET, François et al. Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations. In: Journal of child sexual abuse, 2010, vol. 19, n° 3, p. 337-344. doi: 10.1080/10538711003788991 https://archive-ouverte.unige.ch/unige:20742

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Deposited on : 2012-05-23

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