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Dietary intake of vitamin D and cognition in older women: a large population-based study

Annweiler, C.
Schott, A. M.
Rolland, Y.
Blain, H.
Published in Neurology. 2010, vol. 75, no. 20, p. 1810-1816
Abstract BACKGROUND: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults. METHODS: A total of 5,596 community-dwelling women (mean age 80.5 +/- 0.1 years) free of vitamin D drug supplements from the Epidemiologie de l'Osteoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 mug/wk or recommended >/=35mug/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders. RESULTS: Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 +/- 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 +/- 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (beta = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024). CONCLUSIONS: Weekly dietary intake of vitamin D was associated with cognitive performance in older women.
Keywords AgedAged, 80 and overCognition Disorders/diagnosis/diet therapy/*epidemiologyCohort StudiesComorbidityCross-Sectional StudiesFemaleFood Habits/physiologyHumansMental Status ScheduleProspective StudiesVitamin D/*administration & dosage/metabolismVitamin D Deficiency/complications/epidemiology/prevention & control
PMID: 21079183
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ANNWEILER, C. et al. Dietary intake of vitamin D and cognition in older women: a large population-based study. In: Neurology, 2010, vol. 75, n° 20, p. 1810-1816. doi: 10.1212/WNL.0b013e3181fd6352 https://archive-ouverte.unige.ch/unige:20740

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Deposited on : 2012-05-23

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