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Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study)

Ancelin, Marie-Laure
Carriere, Isabelle
Boulenger, Jean-Philippe
Stewart, Robert
Cristol, Jean-Paul
Ritchie, Karen
Chaudieu, Isabelle
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Published in Biological psychiatry. 2010, vol. 68, no. 2, p. 125-132
Abstract BACKGROUND: Lipids appear to mediate depressive vulnerability in the elderly; however, sex differences and genetic vulnerability have not been taken into account in previous prospective studies. METHODS: Depression was assessed in a population of 1040 women and 752 men aged 65 years and older at baseline and after 7-year follow-up. Clinical level of depression (DEP) was defined as having either a score of 16 or higher on the Centre for Epidemiology Studies Depression scale or a diagnosis of current major depression on the Mini-International Neuropsychiatric Interview. Lipid levels, apolipoprotein E, and serotonin transporter linked promoter region (5-serotonin transporter gene linked promoter region) genotypes were evaluated at baseline. RESULTS: Multivariate analyses adjusted by sociodemographic and behavioral variables, measures of physical health including ischemic pathologies, and genetic vulnerability indicated gender-specific associations between dyslipidemia and DEP, independent of the use of lipid-lowering agents or apolipoprotein E status. Men with low low-density lipoprotein cholesterol levels had twice the risk of prevalent and incident DEP, whereas in women low high-density lipoprotein cholesterol levels were found to be significantly associated with increased prevalent DEP (odds ratio = 1.5) only. A significant interaction was observed between low low-density lipoprotein-cholesterol and 5-serotonin transporter gene linked promoter region genotype, men with s/s or s/l genotype being at increased risk of DEP (odds ratio = 6.0 and 2.7, respectively). No significant gene-environment interaction was observed for women. CONCLUSIONS: DEP is associated with higher atherogenic risk in women (low high-density lipoprotein cholesterol), whereas the reverse is observed in men (low low-density lipoprotein cholesterol). Late-life depression may have a complex gender-specific etiology involving genetic vulnerability in men.
Keywords AgedAged, 80 and overApolipoproteins E/geneticsChi-Square DistributionCholesterol, HDL/*blood/geneticsCholesterol, LDL/*blood/geneticsCross-Sectional StudiesDepressive Disorder/*blood/diagnosis/*geneticsDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesGenotypeHumansInterview, PsychologicalLongitudinal StudiesMaleMultivariate AnalysisPromoter Regions, Genetic/geneticsSerotonin Plasma Membrane Transport Proteins/geneticsSex Factors
PMID: 20537614
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Research group Génétique psychiatrique (4)
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ANCELIN, Marie-Laure et al. Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study). In: Biological psychiatry, 2010, vol. 68, n° 2, p. 125-132. doi: 10.1016/j.biopsych.2010.04.011 https://archive-ouverte.unige.ch/unige:20736

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Deposited on : 2012-05-23

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