Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008

Aebi-Popp, Karoline; Lapaire, Olav; Glass, Tracy R.; Vilen, Louise; Rudin, Christoph; Elzi, Luigia; Battegay, Manuel; Keiser, Olivia; Martinez De Tejada Weber, Begona; Hoesli, I. M.

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Title		Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008
Authors		Aebi-Popp, Karoline Lapaire, Olav Glass, Tracy R. Vilen, Louise Rudin, Christoph Elzi, Luigia Battegay, Manuel Keiser, Olivia Martinez De Tejada Weber, Begona Hoesli, I. M. show all authors [1 - 10]
Collaboration		Swiss mother and child HIV cohort study With : Wyler, Claire-Anne
Published in		Journal of Perinatal Medicine. 2010, vol. 38, no. 4, p. 353-358
Abstract		OBJECTIVE: Rates of vertical HIV transmission between mother and child are low, allowing many HIV positive women to have children with near impunity. In this study, data from the Swiss Mother and Child HIV Cohort Study were used to describe maternal characteristics and their association with pregnancy outcomes in HIV positive women. STUDY DESIGN: HIV positive women were followed prospectively during their pregnancies and deliveries by anonymous questionnaires between January 2003 and October 2008. Adverse pregnancy outcomes included preterm delivery, preeclampsia and gestational diabetes mellitus. RESULTS: This study included 266 HIV positive women, of which 67 (25.2%) were first diagnosed with HIV during pregnancy. Thirty percent (n=80) of the women had pregnancy complications after 24 weeks of gestation. Preterm delivery was noted in 72 (27%) patients. Other complications included preeclampsia (n=7; 2.6%) and gestational diabetes (n=7; 2.6%). Older maternal age was the only risk factor associated with adverse pregnancy outcomes (adjusted odds ratio: 1.06, 95% confidence interval 1.01-1.12, P=0.02). CONCLUSIONS: HIV positive women, especially with advanced maternal age, have high-risk pregnancies and should be monitored as in an interdisciplinary setting. The preponderance of initial HIV diagnosis during pregnancy confirms the importance of HIV screening in pregnant women.
Keywords		Adult — Antiretroviral Therapy, Highly Active — Cohort Studies — Diabetes, Gestational/etiology — Female — HIV Infections/complications/diagnosis/drug therapy/transmission — Humans — Infant, Newborn — Infectious Disease Transmission, Vertical/prevention & control — Maternal Age — Pre-Eclampsia/etiology — Pregnancy — Pregnancy Complications, Infectious — Pregnancy Outcome — Premature Birth/etiology — Prospective Studies — Risk Factors — Switzerland
Identifiers		DOI: 10.1515/JPM.2010.052 PMID: 20184398
Full text		Article - Limited access to UNIGE Other version: http://www.degruyter.com/view/j/jpme.2010.38.issue-4/jpm.2010.052/jpm.2010.052.xml
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie Faculté de médecine / Section de médecine clinique / Département de gynécologie et d'obstétrique
Research groups		Groupe Posfay-Barbe Clara (pédiatrie générale) (853) Etude des altérations du gène ATM dans divers cancers de l'enfant (178)
Citation (ISO format)		AEBI-POPP, Karoline et al. Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008. In: Journal of Perinatal Medicine, 2010, vol. 38, n° 4, p. 353-358. https://archive-ouverte.unige.ch/unige:20723