UNIGE document Scientific Article
previous document  unige:20711  next document
add to browser collection
Title

Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring

Authors
Lepetit-Coiffe, Matthieu
Viallon, Magalie
Published in European Radiology. 2010, vol. 20, no. 4, p. 886-897
Abstract OBJECTIVES: To evaluate the feasibility and effectiveness of magnetic resonance (MR)-guided radiofrequency (RF) ablation for small liver tumours with poor conspicuity on both contrast-enhanced ultrasonography (US) and computed tomography (CT), using fast navigation and temperature monitoring. METHODS: Sixteen malignant liver nodules (long-axis diameter, 0.6-2.4 cm) were treated with multipolar RF ablation on a 1.5-T wide-bore MR system in ten patients. Targeting was performed interactively, using a fast steady-state free precession sequence. Real-time MR-based temperature mapping was performed, using gradient echo-echo planar imaging (GRE-EPI) and hardware filtering. MR-specific treatment data were recorded. The mean follow-up time was 19 +/- 7 months. RESULTS: Correct placement of RF electrodes was obtained in all procedures (image update, <500 ms; mean targeting time, 21 +/- 11 min). MR thermometry was available for 14 of 16 nodules (88%) with an accuracy of 1.6 degrees C in a non-heated region. No correlation was found between the size of the lethal thermal dose and the ablation zone at follow-up imaging. The primary and secondary effectiveness rates were 100% and 91%, respectively. CONCLUSIONS: RF ablation of small liver tumours can be planned, targeted, monitored and controlled with MR imaging within acceptable procedure times. Temperature mapping is technically feasible, but the clinical benefit remains to be proven.
Keywords AgedFemaleHepatectomy/ methodsHumansLiver Neoplasms/ diagnosis/ surgeryMagnetic Resonance Imaging/ methodsMaleMiddle AgedPilot ProjectsSurgery, Computer-Assisted/ methodsThermography/ methods
Identifiers
PMID: 19760231
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.springerlink.com/content/100472/
Structures
Research groups Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
Hépatologie chirurgicale (327)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Citation
(ISO format)
TERRAZ, Sylvain et al. Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring. In: European Radiology, 2010, vol. 20, n° 4, p. 886-897. https://archive-ouverte.unige.ch/unige:20711

180 hits

0 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :