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Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection

Neuhaus, Jacqueline
Jacobs, David R Jr
Baker, Jason V.
Duprez, Daniel
La Rosa, Alberto
Kuller, Lewis H.
Pett, Sarah L.
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Published in The Journal of Infectious Diseases. 2010, vol. 201, no. 12, p. 1788-1795
Abstract BACKGROUND: Human immunodeficiency virus (HIV) replication and immune activation may increase inflammation and coagulation biomarkers. Limited data exist comparing such biomarkers in persons with and without HIV infection. METHODS: For persons 45-76 years of age, levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, D-dimer, and cystatin C were compared in 494 HIV-infected individuals in the Strategies for Management of Anti-Retroviral Therapy (SMART) study and 5386 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study. For persons 33-44 years of age, hsCRP and IL-6 levels were compared in 287 participants in the SMART study and 3231 participants in the Coronary Artery Development in Young Adults (CARDIA) study. RESULTS: hsCRP and IL-6 levels were 55% (P < . 001) and 62 (P < . 001) higher among HIV-infected participants than among CARDIA study participants. Compared with levels noted in MESA study participants, hsCRP, IL-6, D-dimer, and cystatin C levels were 50%, 152%, 94%, and 27% higher, respectively (P < . 001, for each), among HIV-infected participants. HIV-infected participants receiving antiretroviral therapy who had HIV RNA levels 400 copies/mL had levels higher (by 21% to 60%) (P < . 001) than those in the general population, for all biomarkers. CONCLUSIONS: hsCRP, IL-6, D-dimer, and cystatin C levels are elevated in persons with HIV infection and remain so even after HIV RNA levels are suppressed with antiretroviral therapy. Additional research is needed on the pathophysiology of HIV-induced activation of inflammatory and coagulation pathways, to guide potential interventions.
Keywords AdultAgedAnti-HIV Agents/therapeutic useBiological MarkersBlood Coagulation Disorders/*pathologyC-Reactive Protein/analysisCystatin C/bloodFemaleFibrin Fibrinogen Degradation Products/analysisHIV Infections/*complications/drug therapyHumansInflammation/*pathologyInterleukin-6/bloodKidney Diseases/*pathologyMaleMiddle AgedViral Load
PMID: 20446848
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Research group Unité HIV (46)
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NEUHAUS, Jacqueline et al. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. In: The Journal of Infectious Diseases, 2010, vol. 201, n° 12, p. 1788-1795. doi: 10.1086/652749 https://archive-ouverte.unige.ch/unige:20655

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Deposited on : 2012-05-22

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