Scientific article
Open access

Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection

Published inThe Journal of infectious diseases, vol. 201, no. 12, p. 1788-1795
Publication date2010

BACKGROUND: Human immunodeficiency virus (HIV) replication and immune activation may increase inflammation and coagulation biomarkers. Limited data exist comparing such biomarkers in persons with and without HIV infection. METHODS: For persons 45-76 years of age, levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, D-dimer, and cystatin C were compared in 494 HIV-infected individuals in the Strategies for Management of Anti-Retroviral Therapy (SMART) study and 5386 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study. For persons 33-44 years of age, hsCRP and IL-6 levels were compared in 287 participants in the SMART study and 3231 participants in the Coronary Artery Development in Young Adults (CARDIA) study. RESULTS: hsCRP and IL-6 levels were 55% (P < . 001) and 62 (P < . 001) higher among HIV-infected participants than among CARDIA study participants. Compared with levels noted in MESA study participants, hsCRP, IL-6, D-dimer, and cystatin C levels were 50%, 152%, 94%, and 27% higher, respectively (P < . 001, for each), among HIV-infected participants. HIV-infected participants receiving antiretroviral therapy who had HIV RNA levels 400 copies/mL had levels higher (by 21% to 60%) (P < . 001) than those in the general population, for all biomarkers. CONCLUSIONS: hsCRP, IL-6, D-dimer, and cystatin C levels are elevated in persons with HIV infection and remain so even after HIV RNA levels are suppressed with antiretroviral therapy. Additional research is needed on the pathophysiology of HIV-induced activation of inflammatory and coagulation pathways, to guide potential interventions.

  • Adult
  • Aged
  • Anti-HIV Agents/therapeutic use
  • Biological Markers
  • Blood Coagulation Disorders/*pathology
  • C-Reactive Protein/analysis
  • Cystatin C/blood
  • Female
  • Fibrin Fibrinogen Degradation Products/analysis
  • HIV Infections/*complications/drug therapy
  • Humans
  • Inflammation/*pathology
  • Interleukin-6/blood
  • Kidney Diseases/*pathology
  • Male
  • Middle Aged
  • Viral Load
Research group
Citation (ISO format)
NEUHAUS, Jacqueline et al. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. In: The Journal of infectious diseases, 2010, vol. 201, n° 12, p. 1788–1795. doi: 10.1086/652749
Main files (1)
Article (Accepted version)
ISSN of the journal0022-1899

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