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Penumbra system: a novel mechanical thrombectomy device for large-vessel occlusions in acute stroke

Publié dansAmerican journal of neuroradiology, vol. 31, no. 4, p. 628-633
Date de publication2010
Résumé

BACKGROUND AND PURPOSE: Large IC artery occlusion is often resistant to recanalization. We present our initial experience with the PS. MATERIALS AND METHODS: Presenting with a severe acute ischemic stroke, the first 27 consecutive patients were considered for thromboaspiration therapy and retrospective data base analysis. All patients received standard thrombectomy treatment as monotherapy or in combination with thrombolysis or IC stent placement. The primary end point was revascularization of the target vessel to grade 2 or 3 on the TICI scale. Secondary end points were improvement of >4 points on the NIHSS score at discharge and favorable outcome, and improvement in overall mortality at 3 months and in sICH- and procedure-related adverse events. RESULTS: At baseline, the mean age was 66 +/- 14 years and the mean NIHSS score was 14 +/- 7. The anterior circulation was affected in 23 patients, and there were 4 basilar artery occlusions. Intracranial stent placement was performed in 4 patients. A recanalization to TICI 2 or 3 was achieved in 25 patients (93%). None of the patients developed sICH. At hospital discharge, 15 patients (56%) had an NIHSS improvement of >4 and 13 patients (48%) had an mRS score of <2 at 3 months. There was a significant correlation between complete vessel recanalization and favorable outcome. The all-cause mortality at 3 months was 11%. CONCLUSIONS: The PS showed a high potential for recanalization of acute thromboembolic occlusions of the large cerebral arteries. Complete recanalization was strongly correlated with good clinical outcome.

Mots-clés
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Carotid Artery Thrombosis/mortality/radiography/*surgery
  • Catheterization/*instrumentation
  • Cerebral Angiography
  • Combined Modality Therapy
  • Equipment Design
  • Female
  • Fibrinolytic Agents/therapeutic use
  • Humans
  • Image Processing, Computer-Assisted
  • Infarction, Middle Cerebral Artery/mortality/radiography/*surgery
  • Male
  • Middle Aged
  • Retrospective Studies
  • Stents
  • Suction/*instrumentation
  • *Surgical Instruments
  • Survival Rate
  • Thrombectomy/*instrumentation
  • Thrombolytic Therapy
  • Tissue Plasminogen Activator/therapeutic use
  • Tomography, X-Ray Computed
  • Vertebrobasilar Insufficiency/mortality/radiography/*surgery
Citation (format ISO)
KULCSAR, Zsolt et al. Penumbra system: a novel mechanical thrombectomy device for large-vessel occlusions in acute stroke. In: American journal of neuroradiology, 2010, vol. 31, n° 4, p. 628–633. doi: 10.3174/ajnr.A1924
Fichiers principaux (1)
Article (Accepted version)
accessLevelPublic
Identifiants
ISSN du journal0195-6108
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Informations techniques

Création22/05/2012 15:16:04
Première validation22/05/2012 15:16:04
Heure de mise à jour14/03/2023 17:30:45
Changement de statut14/03/2023 17:30:44
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