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Scientific article
English

Combined evaluation of myocardial perfusion and coronary morphology in the identification of subclinical CAD. Radiation exposure of 13N-ammonia PET/CT

Published inNuclear-Medizin, vol. 49, no. 5, p. 173-182
Publication date2010
Abstract

PURPOSE: to evaluate the mean effective radiation dose of 13N-ammonia PET/CT and ECG-pulsing CT angiography (CTA) in the evaluation of myocardial perfusion, myocardial blood flow (MBF) and coronary morphology for the identification of subclinical CAD. PATIENTS, MATERIAL, METHODS: following rest-stress 13N-ammonia PET/CT perfusion imaging and MBF quantification, ECG-pulsing CTA at a pulse window of 70% of the R-R cycle was performed in ten healthy controls and in sixteen individuals with cardiovascular risk factors. Individual radiation dose exposure for ECG-pulsing CTA was estimated from the dose-length product. RESULTS: PET demonstrated normal perfusion in all study individuals, while hyperemic MBFs during dipyridamole stimulation and the myocardial flow reserve (MFR) in cardiovascular risk individuals were significantly lower than in healthy controls (1.34+/-0.26 vs. 2.28+/-0.47 ml/g/min and 1.48+/-0.39 vs. 3.24+/-0.81, both p

Keywords
  • Adult
  • Aged
  • Ammonia/diagnostic use
  • Blood Flow Velocity
  • Coronary Angiography/*methods
  • Coronary Circulation
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Reperfusion/*methods
  • Nitrogen Radioisotopes
  • Positron-Emission Tomography/methods
  • Tomography, Spiral Computed/methods
  • Tomography, X-Ray Computed/methods
Citation (ISO format)
VINCENTI, G. et al. Combined evaluation of myocardial perfusion and coronary morphology in the identification of subclinical CAD. Radiation exposure of 13N-ammonia PET/CT. In: Nuclear-Medizin, 2010, vol. 49, n° 5, p. 173–182. doi: 10.3413/nukmed-0312
Identifiers
ISSN of the journal0029-5566
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